Senior Process Development Lead, Oligonucleotides

Arrowhead Pharmaceuticals, Inc.; Verona (WI); On-site; USD 120,000 - 140,000; Full time

Benefits offered by this job

Competitive benefits

Excellent benefits package

Job summary

Arrowhead Pharmaceuticals, Inc. in Wisconsin seeks a Senior Scientist to lead a team of chemists developing scalable oligonucleotide manufacturing processes.

You will guide process development, optimize synthesis and downstream steps, and support tech transfer to manufacturing for clinical candidates. The role requires a PhD with 4+ years or equivalent experience, strong communication, problem-solving, and expertise in synthetic organic chemistry and analytical methods.

Qualifications

• PhD with 4+ years or equivalent close to senior level.
• Direct experience with solid-phase oligonucleotide synthesis.
• Strong communication and problem-solving skills.

Responsibilities

• Lead a team of chemists in oligonucleotide process development.
• Design and implement scalable manufacturing processes.
• Support technology transfer to manufacturing.
• Collaborate with analytical, QA, and regulatory teams.
• Deliver multigram scale batches for non-GMP activities.

Skills

Solid-phase oligonucleotide synthesis

Downstream processes

Analytical techniques

Communication skills

Problem-solving

Synthetic organic chemistry

cGMP knowledge

Education

PhD in Chemistry

MS in Chemistry

BS in Chemistry

Tools

Cytiva instrumentation

Unicorn software

OP100

Oligosynt

Avant

Job description

Arrowhead Pharmaceuticals, Inc. in Wisconsin seeks a Senior Scientist to lead a team of chemists developing scalable oligonucleotide manufacturing processes.

You will guide process development, optimize synthesis and downstream steps, and support tech transfer to manufacturing for clinical candidates. The role requires a PhD with 4+ years or equivalent experience, strong communication, problem-solving, and expertise in synthetic organic chemistry and analytical methods.