Senior Process Chemist-must have a PhD or Masters

Pulse-39fddc75; Madison (WI); On-site; USD 120,000 - 180,000; Full time

Job summary

Pulse-39fddc75 is seeking a Senior Process Chemist with a PhD or MS and extensive scale-up experience to lead process development in Madison, WI. The role focuses on developing robust chemical processes, scaling routes to multi-kilo reactors, and transferring processes to manufacturing.

Candidates should have strong data analysis, experimental design, and technical writing skills, with experience in LCMS, NMR, and analytical methods. On-site manufacturing environment experience is preferred.

Qualifications

• Ph.D. in Chemistry with 5 years' process chemistry experience, or M.S. in chemistry with 20 years' hands-on chemistry process scale up experience.
• Strong background in data analysis, experimental design, project management, and technical writing proficiencies are required.
• Basic understanding of and willingness to learn statistical concepts; JMP experience would be an advantage.
• Experience with large scale reactors (200L to 2000L) and process equipment.
• Expertise in LCMS, NMR, and other chemical structural analytical methods.
• Demonstrated success working in manufacturing/technical production environments.

Responsibilities

• Provide technical expertise in area of Process Chemistry.
• Independently scout new chemical reaction pathways for future larger-scale use.
• Scale synthetic routes from kilo to multi-kilo scale reactors (400L, 800L, 2000L).
• Develop robust chemical processes transferable to technical manufacturing.
• Identify and implement necessary process equipment for safe, efficient operation.
• Train Chemical Operators and Production Chemist for scaled routes.
• Routinely analyze/interpret 1D/2D NMR spectra to assign structures (1H, 13C).
• Routinely perform/interpret UPLC-MS analyses.
• Assist in data preparation for regulatory filings on chemical syntheses of active ingredients.

Skills

Process chemistry

Scale-up expertise

NMR & LCMS

Data analysis

Experimental design

Project management

Technical writing

Education

Ph.D. in Chemistry

M.S. in Chemistry

Tools

SciFinder

Job description

Senior Process Chemist-must have a PhD or Masters

Location: Madison, WI (on-site)

Job Description:

Provide technical expertise in area of Process Chemistry

Independently scout new chemical reaction pathways that might be useful for future inclusion on larger scale

Scale synthetic routes validated on kilo scale into multi-kilo scale reactors (400L, 800L, 2000L)

Develop robust chemical processes that can be transferred to technical manufacturing/chemical operators

Identify and implement necessary process equipment to ensure safe, efficient operation of technical manufacturing

Train Chemical Operators and Production Chemist to safely perform scaled routes

Routinely analyze and interpret 1-dimension and 2-dimension proton nuclear magnetic

resonance spectra (1D1H-NMR, 2D1H-NMR) to assign molecular structures

Routinely perform and analyze Ultra High-Pressure Chromatography Mass Spectrometry (UPLC-MS)

Assist in the preparation of data for regulatory filings on chemical syntheses of active ingredients

Qualifications:

Ph.D. in Chemistry, with 5 years' experience as process chemist or M.S. in chemistry with 20 years' hands-on chemistry process scale up experience

Strong background in scientific procedure: Data analysis, experimental design, project management, and technical writing proficiencies are required

Basic understanding of and willingness to learn statistical concepts. Previous statistical experience using JMP, or similar statistical software would be an advantage

Expertise with chemical reaction searching database, SciFinder

Experience with large scale reactors (200L to 2000L), process equipment

Expertise in LCMS, NMR, and other chemical structural analytical methods

Demonstrated success working in manufacturing / technical production environments