Senior Process Chemist III - Scale-Up & cGMP

Abzena Inc.; Bristol Township (Bucks County); On-site; USD 85,000 - 125,000; Full time

Job summary

Abzena is seeking a highly motivated Process Chemist III to join the Process Development team. The successful candidate will lead the development, optimization, and scale-up of synthetic processes for small molecules, linker-payloads, intermediates, and related compounds from early development through cGMP manufacturing.

The role requires strong technical expertise, excellent problem-solving skills, and the ability to collaborate effectively with cross-functional teams, including Analytical

Qualifications

• Ph.D. in Organic Chemistry with 2+ years of industrial experience, or
• M.S. in Organic Chemistry with 5+ years of industrial experience, or
• Strong knowledge of synthetic organic chemistry and process development.

Responsibilities

• Design, execute, and optimize synthetic routes for small molecules, intermediates, and complex drug-linker compounds.
• Develop scalable, robust, and cost-effective manufacturing processes suitable for pilot plant and cGMP production.
• Plan and perform laboratory experiments, analyze data, and interpret results to guide process improvements.
• Troubleshoot challenging synthetic and scale-up issues using sound scientific principles.
• Collaborate with Analytical Development, Manufacturing, MSAT, Quality, Supply Chain, and Project Management teams to ensure successful technology transfer and manufacturing campaigns.
• Prepare technical reports, batch records, process descriptions, risk assessments, and technology transfer documentation.
• Maintain accurate laboratory notebooks and ensure documentation complies with company and regulatory standards.
• Mentor junior scientists and provide technical guidance on experimental design and process development.
• Support client meetings by presenting technical data and project updates.
• Contribute to continuous improvement initiatives focused on safety, quality, efficiency, and sustainability

Skills

Organic Chemistry

Process Development

Analytical Techniques

Project Management

Scientific Writing

Education

PhD in Organic Chemistry

MS in Organic Chemistry

Tools

HPLC

LC-MS

NMR

UPLC

Job description

Abzena is seeking a highly motivated Process Chemist III to join the Process Development team. The successful candidate will lead the development, optimization, and scale-up of synthetic processes for small molecules, linker-payloads, intermediates, and related compounds from early development through cGMP manufacturing.

The role requires strong technical expertise, excellent problem-solving skills, and the ability to collaborate effectively with cross-functional teams, including Analytical