Senior Principal Scientist, Protein Expression & Membrane Proteins

Lilly

San Diego (CA)

On-site

USD 72,000 - 189,000

Full time

4 days ago
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Benefits offered by this job

Bonus program
401(k) plan
Vacation benefits
Medical, dental, vision benefits
Flexible benefits
Life insurance
Time off and leave

Job summary

Lilly is seeking a Principal/Senior Principal Scientist in Molecular Biology & Protein Expression to join the LSMD platform in San Diego, CA. The role focuses on cloning, expression across multiple hosts, and platform development with automation and high-throughput workflows.

You will mentor colleagues, design constructs, optimize expression, and drive data integrity and collaboration with downstream teams. On-site, fixed-duration assignment with a standard compensation package.

Qualifications

  • Bachelor’s or Master’s degree in Biological Sciences or related field.
  • Typically 5+ years of hands-on molecular cloning and recombinant protein expression experience.
  • Experience mentoring junior scientists and collaborating across teams.

Responsibilities

  • Design and execute cloning strategies (Gibson, Golden Gate, In-Fusion, mutagenesis).
  • Perform small- and large-scale expression in E. coli, insect, and mammalian cells.
  • Collaborate with purification and structural biology teams to align strategies.
  • Maintain records in LIMS and electronic notebooks.
  • Communicate progress and risks to stakeholders.

Skills

Molecular cloning
Protein expression
Mentoring
Scientific communication
Laboratory automation

Education

B.S./M.S. in Biological Sciences or related

Tools

Benchling
LIMS
AKTA FPLC
Wave bioreactors

Job description

Lilly is seeking a Principal/Senior Principal Scientist in Molecular Biology & Protein Expression to join the LSMD platform in San Diego, CA. The role focuses on cloning, expression across multiple hosts, and platform development with automation and high-throughput workflows.

You will mentor colleagues, design constructs, optimize expression, and drive data integrity and collaboration with downstream teams. On-site, fixed-duration assignment with a standard compensation package.

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