Senior Principal Scientist, Process Chemistry & Scale-Up

SwiftCruit; Kalamazoo (MI); On-site; USD 180,000 - 240,000; Full time

Job summary

Zoetis is seeking an experienced Principal Scientist/Senior Principal Scientist to lead process chemistry efforts for novel veterinary therapeutics. You will design, scale up, and optimize synthetic routes from mg to multi-kilogram scales, integrating green chemistry principles to reduce environmental impact and improve efficiency.

You will guide technology transfer to commercial facilities, manage multiple projects, mentor colleagues, and collaborate with CROs/CMOs in a global setting while

Qualifications

• Ph.D. in Synthetic Organic Chemistry with minimum 8 years in pharma/veterinary process chemistry R&D and at least 2 years in leadership.
• Broad expertise in modern synthetic organic chemistry with proven strategic problem-solving.
• Hands-on experience in process chemistry scale-up to multi-kilogram API manufacturing and tech transfer.
• Experience with risk assessments (process robustness/FMEA, mutagenic impurities, nitrosamines, PFAS, E&L).
• Excellent written and verbal communication skills; ability to influence teams, partners, and management.

Responsibilities

• Lead design, development, and scale-up of chemical syntheses for veterinary therapeutics.
• Independently design and optimize processes from mg to multi-kilogram scale; drive safe, economical transfers.
• Develop impurity control strategies ensuring quality and regulatory compliance.
• Provide strategic direction across multiple projects and mentor team members.

Skills

Process chemistry leadership

Scale-up expertise

Green chemistry

DOE/QbD data-rich experimentation

Education

Ph.D. in Synthetic Organic Chemistry

Tools

SciFinder

Reaxys

HPLC/NMR/GC/LC-MS

Job description

Zoetis is seeking an experienced Principal Scientist/Senior Principal Scientist to lead process chemistry efforts for novel veterinary therapeutics. You will design, scale up, and optimize synthetic routes from mg to multi-kilogram scales, integrating green chemistry principles to reduce environmental impact and improve efficiency.

You will guide technology transfer to commercial facilities, manage multiple projects, mentor colleagues, and collaborate with CROs/CMOs in a global setting while