Senior /Principal Scientist- (Multiple Sclerosis)

Genentech, Inc.; South San Francisco (CA); On-site; USD 121,000 - 224,000; Full time

Job summary

Genentech, Inc. is seeking a senior scientist-level leader to advance biomarker and translational research in multiple sclerosis within the TM-OMNI program.

The role focuses on identifying novel biomarkers, supporting clinical trials, and guiding biomarker-driven decisions in drug development. The position requires a PhD in Neuroscience and/or Immunology with post-doctoral experience, strong leadership, and the ability to collaborate across global teams.

Qualifications

• PhD in Neuroscience and/or Immunology with post-doctoral experience in translational research or drug development.
• Strong independent research track record and ability to mentor others.
• Excellent writing and communication skills with publications or regulatory reports.

Responsibilities

• Identify new targets and biomarkers to support MS drug development.
• Lead data generation and analyses in internal studies or external collaborations.
• Integrate biomarker data into clinical trial programs to inform pathogenesis and treatment strategies.
• Collaborate across Research, Bioanalytical, Clinical, Biostatistics and Regulatory teams and with external partners.

Skills

Independent thinking

Mentorship

Writing

Communication

Cross-functional collaboration

Hypothesis development

Computational analysis

Lab leadership

Education

PhD in Neuroscience and/or Immunology

Tools

Immunoassay

qPCR

Complex in vitro models

Functional genomics

Genomic sequencing

scRNA-seq

TCR-seq

CITE-seq

Spatial transcriptomics

R

Job description

The Position

We advance science so that we all have more time with the people we love.

The Translational Medicine department at Genentech provides translational research to inform clinical development in disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases (TM-OMNI). Our research encompasses cutting edge support of clinical biomarker discovery and development, development of personalized healthcare strategies, and clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches.

We are seeking a highly motivated Senior Scientist or Principal Lab Group Head to join TM-OMNI to drive biomarker and drug development and/or translational research efforts in multiple sclerosis. Our department is responsible for identifying novel approaches to treat MS using clinical translational research; designing, implementing, and interpreting biomarker results; and establishing new ways to speed clinical development in MS through biomarkers. Our group uses relevant human clinical samples and deep molecular and cellular phenotyping approaches to evaluate disease heterogeneity and disease modification by therapeutics to guide assessment of disease pathogenesis and drug discovery and development. Lab Group Heads within the department provide scientific leadership of novel projects to target unmet need in disease, and discover or develop biomarkers to advance clinical trial development.

The Opportunity:

As an integral member of this dynamic team, you will be:

• Working to identify new targets and biomarkers in support of drug development projects in multiple sclerosis.

• Leading efforts to support clinical trials, lead data generation and analyses within internal studies, and/or lead external academic collaborations relating to understanding disease pathogenesis in multiple sclerosis. Success in these responsibilities requires a thorough understanding of disease and drug target biology, creativity and attention to detail, and experience in integrating biomarkers into clinical trials and/or with target identification or validation.

• Familiar with molecular/immunological techniques and analytic methods including immunoassay, qPCR, complex in vitro modeling systems, functional genomics, genomic sequencing, scRNA-seq, TCR-seq, CITE-seq or spatial transcriptomics and/or computational methods/analytics (knowledge of R or Python)

• Working in close partnership across various functions including Research, Bioanalytical Assay Department, Diagnostics, Clinical, Biostatistics, Computational Science, Regulatory and with external partners.

• Providing effective communication with presentations at cross-functional teams, internal review committees, and external conferences: and writing biomarker sections of clinical protocols, reports, regulatory filings and scientific publications.

Who You Are:

• Candidates must have a PhD in Neuroscience and/or Immunology, or a related field with at least 3 years post-doctoral experience in basic or translational research either in an academic and/or industry setting.

• Candidates must demonstrate a high level of independence and must be able to develop hypotheses, direct lab scientists, and develop computational strategies to support analysis and interpretation.

• Candidates should have a record of mentorship (direct reports, students, interns)

• Strong writing and communication skills are required, as evidenced by publications, meeting abstracts and/or drug development reports.

• Candidates will be passionate about using their understanding of disease biology to make impactful contributions to clinical drug development (willingness to collaborate across time zones including our Swiss site is a must).

• Prior experience in multiple sclerosis preferred

• A demonstrated ability to function as part of a cross-functional team such as research or clinical trial project teams.

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $120,700 - 224,100 (Senior Scientist) and $141,500 - 262,900 (Principal Scientist). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.