Senior Principal Protein Scientist & Production Leader

BioSpace; South San Francisco (CA); On-site; USD 180,000 - 223,000; Full time

Benefits offered by this job

Medical/dental/vision coverage

401k

ESPP

Wellness programs

Job summary

IDEAYA Biosciences in South San Francisco seeks a Senior Principal Research Scientist to lead Protein Sciences, supervise a team of researchers, and support multiple drug-discovery programs.

You will develop and execute protein-expression and purification strategies for challenging proteins using bacterial and insect-cell systems, coordinate CROs, and collaborate across disciplines to translate results into program decisions.

Qualifications

• PhD with 9+ years’ hands-on recombinant protein production using bacterial and insect-expression systems.
• Experience developing and troubleshooting purification strategies for proteins and complexes.
• Experience with CROs or external partners for protein production and data transfer.
• Strong history supervising and developing research staff.

Responsibilities

• Lead day-to-day activities of the Protein Sciences team and align with drug-discovery programs.
• Develop and execute protein-expression and purification strategies across systems.
• Oversee construct design, expression testing, purification, and characterization.
• Ensure delivery of high-quality reagents for biochemical, biophysical, and screening use.
• Collaborate with Bioassays, Biophysics, Structural Biology, Biology, and Data Science.
• Manage CROs, review data, and ensure timely, quality deliverables.
• Mentor researchers and provide practical experimental guidance.

Skills

Protein expression

Protein purification

Protein characterization

CRO management

Team supervision

Scientific communication

Education

PhD in a relevant field

Tools

SDS-PAGE

Western blotting

SEC / SEC-MALS

Analytical methods

Job description

IDEAYA Biosciences in South San Francisco seeks a Senior Principal Research Scientist to lead Protein Sciences, supervise a team of researchers, and support multiple drug-discovery programs.

You will develop and execute protein-expression and purification strategies for challenging proteins using bacterial and insect-cell systems, coordinate CROs, and collaborate across disciplines to translate results into program decisions.