Senior Principal ML Scientist: Frontier Biomedical AI

Pfizer Inc; San Diego (CA); Hybrid; USD 139,000 - 232,000; Full time

Job summary

Pfizer is seeking a Senior Principal Machine Learning Scientist to develop frontier AI methods for biomedical research, including foundation models, multimodal and graph-based approaches, and agentic reasoning systems. You will design rigorous experiments, define evaluation standards at scale, and translate results into scientific evidence across drug discovery programs.

You will work with AI researchers, computational biologists, engineers, and domain experts to deploy reusable frameworks and

Qualifications

• PhD and 2+ years experience in Machine Learning, AI, CS, Stats or related field preferred.
• Master’s degree with 5+ years of relevant experience.

Responsibilities

• Develop Frontier AI methods for biomedical research across foundations models and multimodal approaches.
• Design and execute rigorous, controlled experiments with clear hypotheses.

Skills

Intellectual curiosity

Analytical reasoning

Communication

Education

PhD in a quantitative field

Master’s degree in a relevant field

Tools

Python

PyTorch

JAX

Job description

Pfizer is seeking a Senior Principal Machine Learning Scientist to develop frontier AI methods for biomedical research, including foundation models, multimodal and graph-based approaches, and agentic reasoning systems. You will design rigorous experiments, define evaluation standards at scale, and translate results into scientific evidence across drug discovery programs.

You will work with AI researchers, computational biologists, engineers, and domain experts to deploy reusable frameworks and