Senior Principal ML Scientist — Frontier Biomedical AI

Pfizer Inc.; Bothell (WA); Hybrid; USD 139,000 - 232,000; Full time

Benefits offered by this job

Competitive salary

Bonus opportunity

Comprehensive benefits & 401k

Relocation assistance may be available

Job summary

Pfizer is hiring a Senior Principal Machine Learning Scientist to advance AI across the drug discovery and development lifecycle. You will build foundation models, multimodal and graph-based methods, and agentic reasoning systems that generate scientific insights and accelerate experimentation.

You will collaborate with AI researchers, computational biologists, engineers, and domain experts to translate research into trusted capabilities deployed across Pfizer's programs.

Qualifications

• A PhD and 2+ years of experience in Machine Learning, Artificial Intelligence, Computer Science, Statistics, Applied Mathematics, Computational Biology, or a related quantitative field preferred
• A Master's degree with 5+ years of relevant industry or research experience

Responsibilities

• Develop Frontier AI methods for Biomedical Research across foundation models, multimodal and graph-based approaches, generative methods, and agentic reasoning systems.
• Design and execute rigorous, reproducible experiments; compare competing approaches and use evidence to drive decisions.
• Set the evaluation standard at scale with datasets, benchmarks, and validation strategies; measure robustness, calibration, and generalization.
• Translate models into scientific evidence by testing hypotheses with AI engineers, biologists, and domain experts to interpret results and limitations.
• Build reusable foundations, benchmarks, and workflows; enable cross-disease transfer and deployment on common infrastructure.
• Raise the scientific bar by contributing to reviews and mentoring colleagues to raise AI fluency across R&D.

Skills

Python

PyTorch

JAX

Multimodal learning

Graph learning

Statistical analysis

Education

PhD in a quantitative field

Master's degree with 5+ years experience

Job description

Pfizer is hiring a Senior Principal Machine Learning Scientist to advance AI across the drug discovery and development lifecycle. You will build foundation models, multimodal and graph-based methods, and agentic reasoning systems that generate scientific insights and accelerate experimentation.

You will collaborate with AI researchers, computational biologists, engineers, and domain experts to translate research into trusted capabilities deployed across Pfizer's programs.