Senior Principal AI Systems Engineer, Biomedical ML

Pfizer Belgium; Bothell (WA); Hybrid; USD 139,000 - 232,000; Full time

Benefits offered by this job

Relocation assistance

Bonus program (Global Performance Plan

401(k) with Pfizer matching

Health benefits

Job summary

Pfizer is seeking a Senior Principal AI Research Engineer to build and deploy production-grade AI systems that enable scientific discovery. You will own end-to-end platforms, lead architecture decisions, and collaborate with AI scientists, engineers, and platform teams across Pfizer.

You will design scalable data pipelines, evaluation frameworks, and human-in-the-loop workflows, while advancing responsible and trustworthy AI in a regulated, biomedical context.

Qualifications

• PhD or MS with substantial software/systems or ML experience.
• Experience delivering production ML systems and APIs.
• Strong software engineering fundamentals and ownership.
• Experience across AI platforms, MLOps, and scalable infra.

Responsibilities

• Design, develop, and deploy production-grade AI systems.
• Own end-to-end technical delivery from concept to production
• Lead architecture decisions and drive complex projects
• Collaborate with scientists and engineers across teams
• Improve observability, security, and reliability of systems
• Mentor and coach junior engineers

Skills

Python development

PyTorch

JAX

Software architecture

APIs and testing

CI/CD and deployment

Containers and orchestration

Distributed GPU training

MLOps

RAG & knowledge systems

Evaluation frameworks

Performance optimization

Education

PhD in CS/EE/Math or related field

MS with 5+ years relevant experience

BS with 6+ years relevant experience

Tools

PyTorch

JAX

Cloud platforms

Git

Job description

Pfizer is seeking a Senior Principal AI Research Engineer to build and deploy production-grade AI systems that enable scientific discovery. You will own end-to-end platforms, lead architecture decisions, and collaborate with AI scientists, engineers, and platform teams across Pfizer.

You will design scalable data pipelines, evaluation frameworks, and human-in-the-loop workflows, while advancing responsible and trustworthy AI in a regulated, biomedical context.