Senior Pilot-Scale Bioprocess Development Engineer

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 74,000 - 111,000; Full time

Job summary

Vertex Pharmaceuticals LLC in Boston seeks a lab-based Process Development Engineering Senior Scientific Associate to advance large‑scale bioprocess development in a GLP pilot lab. You will execute mammalian and stem cell culture studies in 3–10 L and 50–200 L single‑use bioreactors, ensuring reproducible operations as studies move to pilot scale.

The role involves hands‑on bioreactor prep, seed‑train support, media preparation, sampling, cell counting, harvest, and traceable recordkeeping.

Qualifications

• Bachelor's or Master’s degree in a relevant scientific/engineering field.
• Mammalian cell culture and aseptic laboratory practices required.
• Experience in pilot lab or scale‑up with large‑scale single‑use bioreactors preferred.

Responsibilities

• Plan and execute pilot-scale process-development studies using multiple bioreactor platforms.
• Prepare bioreactor systems for operation and document equipment readiness.
• Support seed-train activities and mammalian/stem cell culture expansion.
• Operate and monitor culture processes, including feeds, perfusion, sampling and harvest.
• Maintain traceable records and collaborate with analytical/engineering teams.
• Coordinate maintenance, calibration, and turnover of equipment in the pilot lab.
• Record activities and contribute to protocols, reports, and study documentation.
• Participate in study planning and troubleshooting to reduce variability during scale‑up.
• Work weekend rotations as needed to support ongoing operations.

Skills

Mammalian cell culture

Aseptic technique

Bioreactor operation

Scale‑up processes

Data integrity

Technical documentation

Cross-functional collaboration

Education

Bachelor's or Master’s degree in a relevant field

Tools

Eppendorf/Sartorius bioreactors

Single-use bioreactor platforms

Benchling

Cell counters

Job description

Vertex Pharmaceuticals LLC in Boston seeks a lab-based Process Development Engineering Senior Scientific Associate to advance large‑scale bioprocess development in a GLP pilot lab. You will execute mammalian and stem cell culture studies in 3–10 L and 50–200 L single‑use bioreactors, ensuring reproducible operations as studies move to pilot scale.

The role involves hands‑on bioreactor prep, seed‑train support, media preparation, sampling, cell counting, harvest, and traceable recordkeeping.