Senior NPI Optical Engineer for Biotech Instrumentation

Nautilus Biotechnology; San Carlos (CA); On-site; USD 145,000 - 196,000; Full time

Job summary

Nautilus Biotechnology seeks a Senior NPI Engineer – Optics to join our instrument operations team, scaling production of our proteomics platform and partnering with R&D, supply chain, and contract manufacturers to ensure high quality and efficient manufacturing.

The role requires 5–7 years in manufacturing or process engineering, strong optical knowledge, and hands-on experience with precision assembly in cleanrooms.

Qualifications

• B.S. or M.S. in Mechanical, Optical, or Manufacturing Engineering.
• 5–7 years in manufacturing or process engineering, preferably in medical devices or life sciences.
• Strong knowledge of optical principles and alignment techniques.
• Experience with precision assembly in cleanrooms.
• Proficiency with GD&T, drawings, and CAD (SolidWorks).
• Familiarity with ISO 13485 / FDA QSR / GMP environments.
• Hands-on SPC, DOE, and FMEA methodologies.
• Data-driven problem solving.

Responsibilities

• Partner with R&D on NPI transfers to production.
• Design and optimize manufacturing processes for optical assemblies and camera integrations.
• Test, calibrate, and align optical modules to meet specs.
• Develop calibration procedures and acceptance criteria.
• Maintain SOPs, traveler sheets, and control plans.
• Develop fixtures and automation to improve yield and throughput.
• Qualify new processes and write IQ/OQ/PQ protocols per ISO/FDA.
• Evaluate processes via FMEA.
• Support supplier qualification and incoming inspection of optics.
• Ensure product and process quality with testing methods.
• Compile reports on trends and performance.
• Train and guide technicians on designs and processes.

Skills

Optical engineering

NPI

Manufacturing process design

GD&T

Cleanroom assembly

Statistical methods

Problem solving

Education

B.S. or M.S. in Mechanical Engineering, Optical Engineering, or Manufacturing Engineering

Tools

SolidWorks

Arena

NetSuite

Interferometers

Spectrometers

Job description

Nautilus Biotechnology seeks a Senior NPI Engineer – Optics to join our instrument operations team, scaling production of our proteomics platform and partnering with R&D, supply chain, and contract manufacturers to ensure high quality and efficient manufacturing.

The role requires 5–7 years in manufacturing or process engineering, strong optical knowledge, and hands-on experience with precision assembly in cleanrooms.