Senior Medicinal Chemistry Project Leader — PROTACs

BioCT Innovation Commons; New Haven (CT); Híbrido; USD 180.000 - 260.000; Jornada completa

Descripción de la vacante

Arvinas in New Haven, CT, is seeking a Medicinal Chemistry Project Leader to drive cross-functional efforts in PROTAC-based drug discovery, with emphasis on degrader‑antibody conjugates, potency optimization, and PK properties.

Reporting to the Executive Director of Medicinal Chemistry, you will guide design and synthesis, interact with external CROs, and communicate data-based strategies to leadership, while balancing project goals and timelines in a hybrid on-site/remote setup.

Formación

• PhD in organic or medicinal chemistry with 8+ years in pharma/biotech drug discovery.
• Experience leading projects to clinical candidate nomination.
• Experience with degrader-antibody conjugates preferred.
• Strong communication and collaboration across teams.

Responsabilidades

• Lead PROTAC project milestones from concept to candidate nomination.
• Design molecules, degrader-antibody conjugates, and libraries with computational resources.
• Perform SAR analysis across datasets to generate hypotheses.
• Coordinate with CROs to meet timelines and standards.
• Present data-driven recommendations to leadership.

Conocimientos

Project leadership

Degrader conjugates

ADC design

SAR analysis

Structure-based design

Pharmacokinetics

Cross-functional teamwork

Senior stakeholder comms

Educación

PhD in organic/medicinal chemistry

Descripción del empleo

Arvinas in New Haven, CT, is seeking a Medicinal Chemistry Project Leader to drive cross-functional efforts in PROTAC-based drug discovery, with emphasis on degrader‑antibody conjugates, potency optimization, and PK properties.

Reporting to the Executive Director of Medicinal Chemistry, you will guide design and synthesis, interact with external CROs, and communicate data-based strategies to leadership, while balancing project goals and timelines in a hybrid on-site/remote setup.