PROTAC Medicinal Chemistry Lead – Hybrid/Onsite

Arvinas; New Haven (CT); Hybrid; USD 180,000 - 280,000; Full time

Job summary

Scorpion Therapeutics in New Haven, CT, seeks a Lead Medicinal Chemist to steer preclinical PROTAC programs and degrader-antibody conjugates toward clinical candidate nomination. You will design and synthesize PROTACs, analyze SAR and multivariate data, and collaborate with external CROs for synthesis and data needs, while providing strategic updates to senior leadership.

The role requires a PhD in organic or medicinal chemistry with 8+ years in pharma/biotech drug discovery and a track record

Qualifications

• PhD in organic or medicinal chemistry.
• 8+ years in pharma/biotech drug discovery.
• Extensive experience with antibody-drug conjugates and structure-based design.
• Strong understanding of pharmacokinetics and in vivo pharmacology.
• Proven project leadership and cross-functional communication skills.

Responsibilities

• Lead design and synthesis of PROTACs and degrader-antibody conjugates.
• Analyze SAR and multivariate datasets to guide optimization.
• Collaborate with external CROs for synthesis and data needs.
• Provide strategic scientific updates to leadership.

Skills

Leadership

Cross-functional communication

Data analysis

Education

PhD in organic or medicinal chemistry

Job description

Scorpion Therapeutics in New Haven, CT, seeks a Lead Medicinal Chemist to steer preclinical PROTAC programs and degrader-antibody conjugates toward clinical candidate nomination. You will design and synthesize PROTACs, analyze SAR and multivariate data, and collaborate with external CROs for synthesis and data needs, while providing strategic updates to senior leadership.

The role requires a PhD in organic or medicinal chemistry with 8+ years in pharma/biotech drug discovery and a track record