Senior Medicinal Chemistry Program Lead

Takeda Pharmaceutical; Boston (MA); Híbrido; USD 154 000 - 243 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Hybrid work model

Resumo da oferta

Takeda in Boston, MA seeks an experienced Medicinal Chemistry Program Leader (Associate Director level) to drive discovery programs from hit-to-lead and nominate candidates. You will lead design, synthesis, and progression of compounds, coordinating internal chemists and CRO partners, delivering milestones within budget.

You will mentor junior chemists, apply cutting-edge design and automation, and contribute to IP while collaborating with biology, pharmacology, and DMPK teams in a hybrid work

Qualificações

• Education and experience: PhD in Organic Chemistry, Medicinal Chemistry, or related discipline with 6+ years in pharma/biotech medicinal chemistry, or MS with 12+ years, or BS with 14+ years.
• Proven track record in discovery programs advancing compounds to candidate nomination or clinic.
• Strong understanding of medicinal chemistry principles, SAR, drug design, and PK/PD relationships.
• Ability to lead cross-functional project teams and drive execution against timelines.
• Experience directing and mentoring chemists, including CRO partnerships.
• Excellent verbal and written communication skills to convey complex science.
• Analytical, proactive problem-solving abilities and adaptability.

Responsabilidades

• Lead medicinal chemistry programs from hit identification through lead optimization and candidate nomination.
• Design and prioritize compounds using SAR, structure-based and computational design, optimizing potency, selectivity, ADME, and safety.
• Serve as chemistry lead on cross-functional teams with biology, pharmacology, DMPK, and toxicology; communicate progress and risks.
• Direct internal chemists and CRO-based teams, set priorities, review plans and data, ensure timely delivery within budget.
• Collaborate with discovery scale-up and process chemistry for tractable synthesis and material supply for in vivo studies.
• Prepare data packages and recommendations for program reviews, go/no-go decisions, and nomination.
• Mentor junior chemists and share best practices in design, synthesis, and data interpretation.
• Apply new methodologies and technologies (computational design, parallel synthesis, automation) to accelerate cycles.
• Contribute to invention disclosures and patent filings; maintain accurate scientific records.

Conhecimentos

Team leadership

Structure-based design

SAR analysis

Cross-functional leadership

Mentoring

Communication

Formação académica

PhD in Organic/Medicinal Chemistry

Descrição da oferta de emprego

Takeda in Boston, MA seeks an experienced Medicinal Chemistry Program Leader (Associate Director level) to drive discovery programs from hit-to-lead and nominate candidates. You will lead design, synthesis, and progression of compounds, coordinating internal chemists and CRO partners, delivering milestones within budget.

You will mentor junior chemists, apply cutting-edge design and automation, and contribute to IP while collaborating with biology, pharmacology, and DMPK teams in a hybrid work