Medicinal Chemistry Program Lead (Hybrid)

Takeda Pharmaceutical Company Limited; Boston (MA); Hybrid; USD 154,000 - 243,000; Full time

Job summary

Takeda Pharmaceutical Company Limited is seeking a hands-on Medicinal Chemistry Program Leader (Associate Director level) to drive discovery programs. You will lead design, synthesis, and progression of compounds, mentoring chemists and coordinating with CROs to deliver milestones from hit-to-lead through nomination.

You will design compounds using SAR and computational methods, lead cross-functional teams, and apply new technologies to accelerate cycles while ensuring high-quality data for

Qualifications

• PhD in Organic or Medicinal Chemistry with 6+ years in pharma/biotech.
• Proven track record leading discovery programs to nomination or clinic.
• Deep understanding of medicinal chemistry, SAR, and drug design.
• Ability to lead cross-functional teams and manage internal/CRO partners.
• Strong communication and mentoring skills.

Responsibilities

• Lead medicinal chemistry programs from hit to lead nomination.
• Design and prioritize compounds using SAR and computational methods.
• Serve as chemistry lead on cross-functional teams with biology, pharmacology, DMPK, and toxicology.
• Direct internal chemists and CRO-based work with clear milestones.
• Coordinate scale-up and supply for in vivo studies.
• Prepare data packages for program reviews and go/no-go decisions.
• Mentor junior chemists and share best practices.
• Apply new technologies to speed design-make-test cycles.
• Contribute to invention disclosures and patent filings.

Skills

Project Leadership

Leadership

Communication

Mentoring

Problem Solving

Cross-functional

CRO Oversight

Design Strategy

Education

PhD in Organic/Medicinal Chemistry

MS with 12+ years experience

BS with 14+ years experience

Job description

Takeda Pharmaceutical Company Limited is seeking a hands-on Medicinal Chemistry Program Leader (Associate Director level) to drive discovery programs. You will lead design, synthesis, and progression of compounds, mentoring chemists and coordinating with CROs to deliver milestones from hit-to-lead through nomination.

You will design compounds using SAR and computational methods, lead cross-functional teams, and apply new technologies to accelerate cycles while ensuring high-quality data for