Senior Medicinal Chemistry Program Lead

Takeda Pharmaceutical Co.; Boston (MA); Híbrido; USD 154 000 - 243 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Hybrid work policy

Resumo da oferta

Takeda Pharmaceutical Co. in Boston seeks a hands-on Medicinal Chemistry Program Leader at the Associate Director level to lead the design, synthesis, and progression of compounds for discovery programs.

You will guide strategy and translate biology targets into potent, selective, and developable molecules. You will mentor chemists, lead cross-functional teams with biology, pharmacology, and DMPK, and oversee CRO partners to deliver milestones from hit-to-lead through candidate nomination.

Qualificações

• PhD or equivalent with extensive medicinal chemistry experience.
• Experience leading discovery programs and delivering candidate nominations.
• Strong understanding of potency, ADME and physical properties.
• Ability to lead cross-functional teams and CRO partners.
• Excellent communication and mentorship skills.
• Proactive problem-solving with data-driven decisions.

Responsabilidades

• Lead medicinal chemistry programs from hit identification through lead optimization and candidate nomination.
• Design and prioritize compounds using SAR and structure-based approaches.
• Lead cross-functional project teams and communicate progress to management.
• Direct internal chemists and CRO-based teams to ensure timely delivery within budget.
• Coordinate with scale-up and process chemistry for in vivo studies.
• Prepare data packages and recommendations for program reviews and go/no-go decisions.
• Mentor junior chemists and promote best practices in design and synthesis.
• Apply new methodologies and automation to accelerate design-make-test cycles.
• Contribute to invention disclosures and patent filings.

Conhecimentos

Medicinal chemistry

SAR

Cross-functional leadership

Project management

Mentorship

Computational design

Data interpretation

Formação académica

PhD in Organic/Medicinal Chemistry

MS in Chemistry

BS in Chemistry

Ferramentas

Computational design software

Structure-based design

Automation in synthesis

Descrição da oferta de emprego

Takeda Pharmaceutical Co. in Boston seeks a hands-on Medicinal Chemistry Program Leader at the Associate Director level to lead the design, synthesis, and progression of compounds for discovery programs.

You will guide strategy and translate biology targets into potent, selective, and developable molecules. You will mentor chemists, lead cross-functional teams with biology, pharmacology, and DMPK, and oversee CRO partners to deliver milestones from hit-to-lead through candidate nomination.