Senior Medicinal Chemist, Induced Proximity Drugs

General Proximity; San Francisco (CA); On-site; USD 150,000 - 210,000; Full time

Benefits offered by this job

Medical, dental, vision

One Medical membership

Equity incentives

Education & health/fitness programs

Books & reading budget

Job summary

General Proximity is a seed-stage drug discovery company in the Bay Area developing induced proximity medicines. We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team and contribute directly to a novel class of therapeutics.

You will design and drive SAR campaigns for next-generation IPMs, lead optimization, and manage external CROs while partnering with Biology and Platform teams to guide compound evaluation in biochemical, biophysical, and cellular

Qualifications

• PhD in Chemistry, Medicinal Chemistry, or a related field.
• Minimum of 5 years of industry experience in small-molecule drug discovery.
• Strong foundation in medicinal chemistry and its application to disease-focused drug discovery.
• Experience designing, synthesizing, and optimizing induced proximity medicines, including PROTACs or related approaches.
• Experience across hit finding, hit-to-lead, and lead optimization.
• Demonstrated success optimizing compounds for oral exposure and interpreting PK data across multiple species.
• Deep understanding of physicochemical properties and in vitro DMPK parameters.
• Experience managing external chemistry CROs and driving synthetic programs efficiently.
• Excellent written and verbal communication skills.

Responsibilities

• Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including bifunctional and molecular glue-related modalities.
• Lead compound design and SAR campaigns from hit finding and HTS follow-ups through hit-to-lead and lead optimization.
• Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review.
• Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression.
• Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays.
• Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction.
• Support intellectual property strategy through invention generation and contributions to patent filings.
• Help evaluate and expand opportunities into new disease areas and therapeutic applications.

Skills

Medicinal chemistry

Induced proximity medicines

Lead optimization

HTS follow-ups

Pharmacokinetics interpretation

External CRO management

Scientific communication

Education

PhD in Chemistry, Medicinal Chemistry, or related field

Tools

Computational chemistry

Molecular modeling

Molecular dynamics

Job description

General Proximity is a seed-stage drug discovery company in the Bay Area developing induced proximity medicines. We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team and contribute directly to a novel class of therapeutics.

You will design and drive SAR campaigns for next-generation IPMs, lead optimization, and manage external CROs while partnering with Biology and Platform teams to guide compound evaluation in biochemical, biophysical, and cellular