Senior Medicinal Chemist — Drug Discovery Lead

Altos Labs; San Francisco (CA); On-site; USD 165,000 - 316,000; Full time

Job summary

Altos Labs in California is seeking a talented Medicinal Chemist to advance science and develop life-changing medicines. You will impact all stages of drug discovery, from hit identification to lead optimization, in a collaborative, fast-paced environment.

You possess a Ph.D. in Organic Chemistry with 6+ years of post-PhD experience and proven expertise in modern synthetic/medicinal chemistry, structure-based design, and cross-functional collaboration.

Qualifications

• Ph.D. in Organic Chemistry with 6+ years post-PhD experience.
• Proven synthetic/medicinal chemistry expertise with lead author publications and/or patents.
• Experience in the drug discovery process from hit identification to lead optimization.
• Structure-based drug design experience.
• Strong verbal and written communication skills.
• Collaborative team player with results-oriented mindset.
• Ability to design and synthesize novel compounds and manage CROs.

Responsibilities

• Drive design and synthesis of drug-like molecules for discovery programs.
• Collaborate across functions including DMPK, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and biology.
• Analyze SAR data to guide program direction and decision making.
• Advance compounds toward development candidate selection and optimize properties.
• Provide broad chemistry support and coordinate with CROs and internal teams.

Skills

Organic Chemistry

Medicinal Chemistry

Drug Discovery

Structure-Based Design

Communication

Collaboration

Problem Solving

Education

Ph.D. in Organic Chemistry

6+ years post-Ph.D. experience

Job description

Altos Labs in California is seeking a talented Medicinal Chemist to advance science and develop life-changing medicines. You will impact all stages of drug discovery, from hit identification to lead optimization, in a collaborative, fast-paced environment.

You possess a Ph.D. in Organic Chemistry with 6+ years of post-PhD experience and proven expertise in modern synthetic/medicinal chemistry, structure-based design, and cross-functional collaboration.