Senior Medical Director

Sagimet Biosciences; Foster City (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

Sagimet Biosciences is seeking a Senior Medical Director to lead clinical trial planning and execution in dermatology-related programs. You will drive trial design, data interpretation and regulatory submissions, working with cross-functional teams to advance novel therapies.

The role requires MD with board certification and 5+ years in clinical development, with dermatology experience a plus. Excellent communication and leadership skills are essential in a fast-paced biotech environment.

Qualifications

• MD with board certification required for leadership in clinical development.
• Minimum 5+ years in clinical development within biotech/pharma.
• Experience in regulatory interactions and NDA/BLA filings is a plus.
• Proven ability to communicate clinical results to diverse audiences.
• Strong leadership, collaboration and strategic thinking skills.
• Ability to thrive in a fast-paced, small company environment.

Responsibilities

• Design, analysis, interpretation and reporting of clinical trials.
• Medical leadership for study protocols, ICAs, CSRs and regulatory submissions.
• Monitor ongoing trials for protocol adherence and safety compliance.
• Review safety events, SAEs, and regulatory safety requirements.
• Collaborate with Clinical Operations, Regulatory, Safety, Biomarkers, Biostatistics and Medical Writing.
• Provide scientific leadership for trial design, endpoints and patient selection.
• Represent Sagimet at scientific meetings and with key opinion leaders.
• Stay current on therapeutic areas and industry advances.

Skills

Clinical leadership

Study design

Data analysis

Regulatory collaboration

Scientific communication

Education

MD with board certification

Dermatology experience

Job description

As a Senior Medical Director, you will play a critical role in planning and executing Sagimet’s clinical trial programs. You will collaborate closely with cross-functional team members, including representatives from Clinical Operations, Regulatory Affairs, Safety Pharmacovigilance, Translational Sciences and Biomarkers, Biometrics, Medical Writing, Research & Development, and Program Management. Your expertise will drive successful planning, execution, analysis and reporting of clinical trials and contribute to the advancement of novel therapies.

Clinical Development

• Design, analysis, interpretation, and reporting of clinical trials.
• Medical leadership for the development of clinical study protocols, Investigator Brochures, Clinical Study Reports, regulatory submissions, and other study-related documents.
• Monitor ongoing clinical trials, ensuring adherence to protocols, safety guidelines, and regulatory requirements.
• Review safety events, adverse reactions, and serious adverse events (SAEs).

Collaboration and Leadership

• Work closely with the Clinical Operations team to support trial execution.
• Key medical contact for study investigators, DSMBs, IRBs.
• Provide scientific and strategic leadership, contributing to trial design, endpoints, and patient selection.
• Collaborate with cross‑functional team members to develop scientifically sound clinical trial protocols, statistical analysis plans and other study documents that are feasible to execute.
• Contribute to interactions with regulatory authorities and regulatory submissions.
• Collaborate with study investigators in the preparation, submission, and presentation of scientific data at scientific meets and congresses.
• Maintain current knowledge of therapeutic areas and industry advancements through conferences, literature, and training.
• Represent the company at scientific conferences and engage with key opinion leaders.

Education and Experience

• Medical degree (MD) with board certification, dermatology experience would be a plus.
• 5+ years of experience in clinical development within the biotechnology or pharmaceutical industry with expertise in clinical trial design, execution, and data analysis.
• Expertise in dermatology studies would be a plus.
• Experience in regulatory interactions, submissions, and/or NDA/BLA filings.
• Experience in scientific communication of clinical results through presentations to internal and external audiences, abstracts and publications.
• Excellent verbal and written communication skills, ability to collaborate effectively with thought leaders and investigators.
• Ability to provide scientific and strategic leadership.
• Ability to work in a fast‑paced, small company environment with multiple competing responsibilities.