Senior Manager, QSP & Data Analytics

Sarepta Therapeutics; City of Rochester (MA, NY); Remote; USD 132,000 - 165,000; Full time

Job summary

An innovative firm at the forefront of genetic medicine is seeking a Senior Manager of QSP & Data Analytics. In this pivotal role, you will design and develop mechanistic models that bridge preclinical insights with clinical outcomes, leveraging advanced data analytics and AI/ML approaches. This position offers the opportunity to work collaboratively with cross-functional teams, transforming complex biological systems into actionable insights. Join us in shaping the future of drug development and making a significant impact on patients' lives. If you are a solution-oriented thinker who thrives in a dynamic environment, we encourage you to apply.

Benefits

Physical and Emotional Wellness Programs

Financial Wellness Resources

Support for Caregivers

Qualifications

• 2+ years of experience in quantitative sciences and drug development.
• Strong background in QSP modeling and data analytics.

Responsibilities

• Design and develop mechanistic QSP models for drug development.
• Implement AI/ML solutions to enhance QSP strategies.

Skills

Quantitative Systems Pharmacology (QSP)

Data Analytics

AI/ML Approaches

Programming (Python, MATLAB, R, C, C++)

Communication Skills

Education

PhD in Bioengineering

PhD in Chemical Engineering

PhD in Computational Biology

Tools

NONMEM

Monolix

NumPy

SciPy

Pandas

ggplot

Job description

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), with over 40 programs in various stages of development in gene therapy, RNA, and gene editing. In 2023, we launched our fourth therapy and the first gene therapy to treat Duchenne.

We're seeking individuals who see unlimited potential in themselves and are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we deeply care about our community and believe in supporting all aspects of their lives. We strive to foster a culture where people bring their whole selves to work and help everyone integrate work and personal life while maintaining productivity. Our benefits and work-life resources support:

• Physical and Emotional Wellness

• Financial Wellness

• Support for Caregivers

For a full list of our benefits, visit: https://www.sarepta.com/join-us

The Importance of the Role

Join us in shaping the future of drug development through innovative quantitative systems pharmacology (QSP) and advanced data analytics. As a Senior Manager of QSP & Data Analytics, you'll apply mechanistic modeling to bridge preclinical insights and clinical outcomes, develop and implement QSP models integrating disease biology, drug mechanisms, and patient variability to guide drug development decisions, and leverage modern data analytics and AI/ML approaches to extract insights from diverse data sources. Working with cross-functional teams, you will transform complex biological systems into mathematical frameworks to advance life-changing medicines.

The Opportunity to Make a Difference

• Design and develop mechanistic QSP models to reveal insights about disease biology and drug-system interactions across therapeutic areas
• Apply QSP approaches to inform dose selection, study design, and patient targeting
• Integrate preclinical and clinical data through innovative model-based analyses to bridge translational gaps
• Prepare regulatory documentation and responses to health authority questions to build confidence in model-based approaches
• Implement cutting-edge data analytics and AI/ML solutions to enhance QSP strategies
• Develop automated tools and visualizations to communicate model insights effectively
• Represent modeling analyses in cross-functional teams and translate technical results into actionable insights
• Contribute to scientific publications and present at conferences to advance the field

More about You

• PhD in bioengineering, chemical engineering, biophysics, computational biology, mathematics, pharmacometrics, pharmaceutical sciences, or related fields; 2+ years of experience at the interface of quantitative sciences and drug development
• Strong background in QSP modeling with ability to translate biological systems into mathematical frameworks, complemented by data analytics and pharmacometrics experience
• Familiarity with modern data analytics and AI/ML approaches is a plus
• Proficiency in programming languages (Python, MATLAB, R, C, C++) including libraries like NumPy, SciPy, Pandas, ggplot, etc.
• Experience with pharmacometrics software (e.g., NONMEM, Monolix) is a plus
• Excellent communication skills and ability to collaborate in cross-functional teams

What Now?

We're looking for solution-oriented, critical thinkers comfortable with ambiguity and candor, who enjoy challenging themselves and value kindness and integrity. If this describes you, we encourage you to apply.

#LI-Remote#LI-TD1

This position is remote, but you may be required to work onsite at Sarepta facilities in the U.S. and attend company-sponsored events. The salary range is $132,000 - $165,000 annually, based on experience and other factors. Candidates must be authorized to work in the U.S. Sarepta offers competitive compensation and benefits. We are an Equal Opportunity/Affirmative Action employer and participate in e-Verify.