Senior Manager People Systems and Operations

Olema; San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Olema Oncology seeks a Senior Manager of People Systems and Operations to lead the HR technology stack from our San Francisco office. You will own HRIS strategy, governance, and data analytics, partnering with IT, Finance, and Talent Acquisition to drive scalable reporting and seamless integrations.

This role requires hands-on leadership and a track record of delivering leverage through HR tech. Based in San Francisco, you will guide system implementations (BambooHR, Greenhouse, OrgChart, Pave,

Qualifications

• Experience leading HRIS strategy and governance.
• Ability to design scalable HR analytics and dashboards.
• Strong cross-functional collaboration with IT and Finance.

Responsibilities

• Own HRIS landscape including selection, config, and upgrades.
• Ensure data integrity, compliance, and scalable reporting.
• Partner with IT, Finance and TA to drive integrations and analytics.

Skills

HR leadership

Data analytics

Cross-functional collaboration

Tools

BambooHR

Culture Amp

Greenhouse

OrgChart

Pave

ADP

Okta

Fidelity

FlexSpring

Job description

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it's an exciting time to be part of Team Olema.

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity.

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape - particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer's darolutamide in metastatic castration-resistant prostate cancer by the end of this year.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day.

If you're ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together - for our patients, for your career, and for what's beyond.

About the Role >>> Senior Manager People Systems and Operations

The Senior Manager People Systems and Operations is a strategic and hands-on leader responsible for the design, optimization, and management of Olema's HR technology ecosystem. This role serves as the central point of expertise across HR, Talent Acquisition, IT, and Finance systems, ensuring data integrity, scalable reporting, and seamless system integrations.

This individual will play a critical role in advancing Olema's HR data maturity - from largely manual, reactive reporting to automated, insight-driven analytics that inform organizational health, workforce planning, and executive decision making. This role will also drive the evolution of HR systems and processes to support business growth, scalability, and cross-functional needs.

This role is based out of our San Francisco office.

Your work will primarily encompass:

HR Systems Leadership & Optimization

• Serve as the primary owner and subject matter expert for all HR systems, including BambooHR, Culture Amp, Greenhouse, OrgChart, Pave, ADP, and related platforms.
• Lead system configuration, testing, troubleshooting, and ongoing enhancements.
• Manage onboarding and offboarding workflows across systems to ensure a seamless employee experience.
• Conduct regular data audits to maintain accuracy, compliance, and system integrity.
• Oversee system implementations (e.g., OrgChart, Pave) and lead future HR technology rollouts to expand capabilities.
• Manage HRIS vendors, including contract renewals and performance oversight.
• Continuously evaluate and implement new tools and system enhancements to support organizational scale and efficiency.

Cross-Functional Systems Integration (HR, IT, Finance)

• Partner with IT to manage and expand system integrations (e.g., Okta, BambooHR, ADP), ensuring seamless and secure data flow across platforms.
• Support implementation and optimization of integration tools (e.g., FlexSpring).
• Collaborate with Finance on systems such as Fidelity and workforce-related data needs, expanding HRIS support to financial and operational reporting.
• Actas a liaison acrossHR,IT,TA,andFinancetoalignsystemstrategiesanddriveenterprise‑w

Data Analytics & Reporting Strategy

• Design, build, and implement scalable, automated reporting solutions and dashboards for HR, TA,