Senior Manager Digital Manufacturing & Shopfloor Innovation, CVRM

Genentech; Holly Springs (MS); On-site; USD 180,000 - 240,000; Full time

Job summary

Genentech in Holly Springs, NC, is launching a state-of-the-art digital manufacturing hub. The Senior Manager of Digital Manufacturing & Shopfloor Innovation leads the transformation of physical factory operations into a connected digital shopfloor, bridging advanced automation with real-time data analytics.

This role combines hands-on technical execution, program management, and adoption leadership to deploy the Digital Twin framework, paperless manufacturing, immersive technologies (AR/VR),

Qualifications

• Experience implementing Digital Twin framework(s) for manufacturing.
• Familiar with automation, data analytics and digital tools in a plant.
• Strong leadership of cross-functional teams and change management.

Responsibilities

• Own the site Digital Twin roadmap and its integration with real-time data.
• Lead UAT, model validation, and business acceptance with Operations, Engineering, Quality, Warehouse, and IT SMEs.
• Drive adoption of digital twin tech and empower operators with real-time insights.
• Coordinate inputs from internal teams and external partners for simulation models.
• Manage budget for digital twin software enhancements, licenses, and infrastructure.

Job description

Welcome to Holly Springs, North Carolina- home to Roche/Genentech's largest-ever investment: a $2B greenfield start-up where next-generation technology, high-performing teams and Operational Excellence converge to create the global standard for high-volume, highly-efficient Drug Product manufacturing.

The facility's core is defined by Innovation - leveraging advanced automation, robotics, digital tools, real-time data analytics, and simple, streamlined processes to produce the highest quality medicines. This plant meets today's demand for CVRM (Cardiovascular, Renal, and Metabolism) medicines and is scalable to grow with the portfolio, which focuses on next-generation metabolic medicines specifically targeting the global obesity epidemic and Type 2 diabetes. This is a fast-paced, entrepreneurial environment with a high-level of accountability, with planned launch in 2028.

Are you a problem-solver and change-agent who thrives in a Team environment, eager to tackle the most complex manufacturing challenges? If so, this is a once-in-a-lifetime opportunity to launch a state-of-the-art facility from the ground-up and shape the culture of our organization for the next generation.

Join us in Holly Springs, where you won't just build a plant-you will build the future of medicine.

The Opportunity

The Senior Manager of Digital Manufacturing & Shopfloor Innovation is the site's operational and technical leader responsible for transforming physical factory operations into a seamlessly connected, digital shopfloor. This is a hands-on people leadership role combining technical execution, program management, adoption leadership, and team development. You drive the implementation of enabling digital technologies-including the Digital Twin framework, paperless manufacturing solutions, immersive technologies (AR/VR), and connected worker systems-to empower plant operators, improve batch execution, and maximize plant performance.

Your mission is to bridge the gap between complex digital platforms and daily shopfloor operations, ensuring operators have real-time data visibility, seamless connectivity to plant systems, and the insights they need to make better decisions. You own the site Digital Twin roadmap as a key enabler of operator empowerment and operational excellence, while simultaneously architecting the complete digital shopfloor experience. This role demands both technical depth (simulation validation, AR/VR testing, workflow design) and strong people leadership to drive adoption across all operational functions.

What You’ll Do

Time Allocation: Technical Execution (30%) | Program Management (40%) | Adoption & Change Leadership (10%) | People Leadership (20%)

Digital Twin & Plant Modeling as Key Enabler (Major Pillar) Product Ownership & Lifecycle Management:

• Own the site Digital Twin roadmap, ensuring seamless integration between physical assets, real-time operational data, and predictive simulation models that drive shopfloor decision-making
• Own the site Digital Twin demand and backlog, translating business needs (especially operator-facing use cases) into clearly defined requirements with owners, identifying relevant KPIs, data requirements, and acceptance criteria
• Lead use cases from intake and prioritization through simulation development, validation, implementation, and benefit realization-with a focus on shopfloor operator value
• Coordinate required inputs from internal teams and external partners (process data, layouts, equipment information, automation logic, 3D/BIM data)
• Hands-on technical work: Identify simulation requirements and collaboratively work with 3rd-party simulation expert teams to develop and enhance models; validate new simulations for fidelity and accuracy; ensure the digital twin accurately reflects real-world plant conditions as they evolve
• Coordinate UAT, model validation, and business acceptance with Operations, Engineering, Quality, Warehouse, and IT/Data SMEs
• Define and manage the site budget for digital twin software enhancements, licenses, infrastructure upgrades, and vendor support

Digital Twin Adoption & Operator Enablement:

• Serve as the primary advocate for digital twin technology, driving user adoption across all business functions (especially Operations, Warehouse, Training, Quality, and Engineering)
• Support user onboarding, training, and adoption-with particular focus on enabling operators and supervisors to leverage digital twin insights in real-time
• Act as the main site interface to the Global Digital Twin Product Owner, ensuring alignment with common standards, governance, and reusable solutions across sites
• Build and lead a community of super-users (shift supervisors, lead operators, engineers), coaching site personnel to incorporate twin-driven insights into daily work routine (e.g., yield optimization, predictive maintenance, bottleneck removal)
• Communicate progress, risks, and ROI transparently across all site levels-upwards to executive