Senior Manager, Commercial Supply Chain

mirumpharmaceuticals; Foster City (CA); On-site; USD 150,000 - 190,000; Full time

Job summary

Mirum Pharmaceuticals in Foster City, CA seeks a Senior Manager, Commercial Supply Chain to lead domestic and international distribution, O2C operations, and inventory management for the commercial portfolio and new product launches. You will partner with 3PLs, Finance, Quality, Regulatory, and external partners to ensure compliant, timely product delivery globally.

This role drives end-to-end planning, demand and supply alignment, and readiness for market expansions, while maintaining product

Qualifications

• Bachelor's degree in Supply Chain Management, Business Administration, Operations Management, Logistics, or a related field.

Responsibilities

• Lead domestic and international commercial distribution operations.
• Oversee order-to-cash (O2C) activities with 3PL partners and Finance.
• Manage finished goods inventory across North American 3PLs with accuracy and shelf-life control.

Skills

3PL management

O2C processes

GDP/GMP knowledge

Cross-functional collaboration

Global logistics

Education

Bachelor's degree in Supply Chain Management/Business/Operations/Logistics

Job description

MISSION

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we're looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.

POSITION SUMMARY

Mirum Pharmaceuticals is seeking an experienced, highly motivated, and detail-oriented Senior Manager, Commercial Supply Chain to support its growing global commercial portfolio and new product launches. This position will be primarily responsible for managing domestic and international commercial distribution, inventory management, and order-to-cash (O2C) operations to ensure timely, accurate, and compliant product delivery across global markets. In addition, the role will support end-to-end (E2E) commercial supply planning activities, including demand and supply alignment, labeling and packaging coordination, and finished product supply execution, while developing the capabilities to provide effective planning backup and ensure business continuity. The successful candidate will collaborate closely with cross-functional teams and external supply chain partners to drive operational excellence, maintain uninterrupted commercial supply, and support patient access.

JOB FUNCTIONS/RESPONSIBILITIES

• Lead domestic and international commercial distribution operations to ensure timely, accurate, and compliant product delivery across global markets.
• Oversee order-to-cash (O2C) activities, including customer order management, inventory allocation, order fulfillment, shipment execution, and reconciliation in collaboration with Commercial Operations and Finance.
• Manage commercial finished goods inventory across North American 3PLs, ensuring inventory accuracy through regular reconciliation, product availability, timely replenishment, and effective shelf-life management.
• Manage relationships and operational performance of 3PLs, distributors, and logistics partners, including KPI development and monitoring, business reviews, and issue resolution.
• Support new product launches, market expansion, distribution network readiness, supplier qualification, and implementation of new distribution partners
• Collaborate with Quality and other cross-functional teams to ensure distribution compliance and support deviation investigations, change controls, CAPAs, and other quality-related activities, as applicable.
• Drive continuous improvement of distribution, inventory management, and O2C processes through standardized procedures, system enhancements, and operational efficiencies.
• Support E2E commercial supply planning activities, aligning demand, manufacturing, labeling and packaging, inventory, and distribution to ensure product availability.
• Collaborate with CMOs, CPOs, and cross-functional teams to monitor manufacturing and packaging schedules, component availability, finished product readiness, and supply execution.
• Support inventory projections, replenishment planning, supply-demand reconciliation, and proactive identification and mitigation of supply risks.
• Participate in commercial labeling and packaging planning, including packaging readiness, market-specific supply requirements, and new product introductions.
• Develop proficiency in E2E commercial planning processes, systems, and master data to provide effective backup support for supply planning and labeling and packaging activities.
• Support supply chain transitions, business continuity, and continuous improvement initiatives while staying informed of regulatory changes impacting commercial supply planning and distribution.

QUALIFICATIONS

• Education /Experience:
• Bachelor's degree in Supply Chain Management, Business Administration, Operations Management, Logistics, or a related field.
• Minimum of 8 years of progressive experience in commercial supply chain, distribution, logistics, inventory management, or order-to-cash operations within the pharmaceutical or biotechnology industry.
• Demonstrated experience managing domestic and international commercial distribution operations, including third-party logistics (3PL) providers and external distribution partners.
• Strong understanding of order-to-cash processes, including customer order management, order fulfillment, inventory allocation, shipment execution, and reconciliation.
• Working knowledge of pharmaceutical Good Distribution Practices (GDP), Good Manufacturing Practices (GMP), and applicable regulatory and distribution requirements.
• Experience with international logistics, import/export requirements, customs clearance, Incoterms, and temperature-controlled pharmaceutical transportation.
• Experience collaborating with cross-functional teams, including Commercial Operations, Finance, Quality, Regulatory Affairs, and external supply chain partners.
• Demonstrated abili