Senior LC-MS Bioanalytical Scientist - DMPK Focus

alloytherapeutics; Waltham (MA); On-site; USD 126,000 - 150,000; Full time

Benefits offered by this job

Unlimited PTO

Annual continuing education stipend

Wellness & EAP programs

Job summary

Alloy Therapeutics in Waltham, MA is seeking a hands-on scientist with strong LC-MS expertise to lead bioanalytical characterization of oligonucleotide therapeutics, focusing on DMPK and biological interpretation.

This LC-MS focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, and protein binding to inform PK/PD and biological activity, with collaboration across teams.

Qualifications

• Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field.

Responsibilities

• Develop and execute LC‑MS/MS and LC‑HRMS methods for quantitative and structural analysis of oligonucleotides in biological matrices.
• Perform stability, degradation, and MetID studies to support DMPK.
• Interpret LC‑MS data within a DMPK context and link findings to PK/PD and biology.
• Clearly communicate analytical and DMPK insights to inform decision-making.

Skills

LC-MS/MS

LC-HRMS

Oligonucleotide exposure/ binding

Data interpretation

Cross-functional communication

Education

Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related field

Tools

LC-MS

HRMS

Job description

Alloy Therapeutics in Waltham, MA is seeking a hands-on scientist with strong LC-MS expertise to lead bioanalytical characterization of oligonucleotide therapeutics, focusing on DMPK and biological interpretation.

This LC-MS focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, and protein binding to inform PK/PD and biological activity, with collaboration across teams.