Senior LC-MS Bioanalysis Scientist, Oligonucleotides

Alloy Therapeutics, Inc.; Waltham (MA); On-site; USD 126,000 - 150,000; Full time

Benefits offered by this job

401(k) company match

Generous medical, dental, and vision benefits

Unlimited PTO and flexible schedules

Annual stipend for continuing education

Wellness and Employee Assistance Program (EAP)

Job summary

Alloy Therapeutics, Inc. is seeking a hands-on scientist with expertise in LC-MS to lead the bioanalytical characterization of oligonucleotide therapeutics in Waltham, MA. This role is crucial for linking analytical data to DMPK-relevant questions to enhance drug development.

The ideal candidate will have a Ph.D. or M.S., with a strong background in LC-MS and oligonucleotide bioanalysis. Benefits include competitive compensation, unlimited PTO, and comprehensive health plans.

Qualifications

• Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field.
• 3+ years (Ph.D.) or 10+ years (M.S.) of post-academic experience.
• Demonstrated experience with LC-MS and high-resolution MS oligonucleotide bioanalysis.

Responsibilities

• Develop and execute LC-MS/MS and LC-HRMS methods for oligonucleotide analysis.
• Apply LC-MS to assess oligonucleotide–protein interactions.
• Collaborate with cross-functional teams to integrate DMPK findings.
• Perform quantitative LC-MS data analysis and troubleshoot.

Skills

LC-MS/MS

Oligonucleotide exposure

Stability

Metabolism

DMPK data interpretation

Cross-functional communication

Education

Ph.D. or M.S. in Analytical Chemistry

Tools

LC-MS

High-resolution MS (HRMS)

Job description

Alloy Therapeutics, Inc. is seeking a hands-on scientist with expertise in LC-MS to lead the bioanalytical characterization of oligonucleotide therapeutics in Waltham, MA. This role is crucial for linking analytical data to DMPK-relevant questions to enhance drug development.

The ideal candidate will have a Ph.D. or M.S., with a strong background in LC-MS and oligonucleotide bioanalysis. Benefits include competitive compensation, unlimited PTO, and comprehensive health plans.