Senior Immunology Scientist - Immunogenicity & AOC Platforms

Novartis; Cambridge (MA); On-site; USD 99,000 - 183,000; Full time

Job summary

Novartis in Cambridge, MA is seeking a senior scientist specializing in human immunology and immune profiling to lead immunology-focused studies on novel biotherapeutics, including AOCs and xRNA approaches.

You will design immune profiling assays, work with primary cells and multicolor FACS, generate mechanistic data for candidate optimization, and collaborate across disciplines to inform safety and translational strategies.

Qualifications

• Recent Ph.D. graduate (0-1 year) or MSc in Life Science, preferably immunology or cell biology plus 2-5-year research experience in human immunology or cell biology in industry or academic settings.
• Deep expertise in human immunology and immune assay development, preferably using primary immune cells, multicellular assay systems, tissue-relevant models, or disease-relevant ex vivo platforms.
• Experience assessing immunogenicity, immune activation, cytokine release, anti-drug immune responses, or immune-related liabilities for biologics or emerging therapeutic modalities.
• Proficiency with immunological and molecular readouts such as flow cytometry, immunoassays, qPCR, transcriptomics or imaging.
• Scientific curiosity, initiative, commitment, flexibility and good organization and presentation skills.
• Work independently and as a team member with open communication with groups and collaborators.

Responsibilities

• Design, establish, and execute immunology-focused profiling strategies to evaluate immune cell activation, modulation, cytokine release, innate immune sensing, adaptive immune responses, and disease-relevant functional outcomes.
• Competent and independent in executing and analyzing complex assays involving primary cells, multicolor FACS analysis and functional immunological assays
• Generates hypotheses, designs and executes experiments, critically analyzes and interprets data, able to prioritize experiments and design follow-up experiments
• Generate mechanistic immunology data packages to support candidate optimization, translational biomarker hypotheses, safety risk assessment, and decision-making across discovery and early development programs.
• Collaborate closely with teams in immunology, disease biology, oligonucleotide biology, antibody engineering, bioanalytics, toxicology, and translational medicine to align assay strategy with program needs.
• Regularly communicate and present results, prepare reports, representing the Unit in project teams
• Open mindset, organization skills and ability and eagerness to develop novel assays or analysis tools based on project needs in different disease areas
• Maintain familiarity with scientific and technical literature pertinent to the projects

Skills

Immunology

Immune assays

Flow cytometry

qPCR

Transcriptomics

Imaging

Education

PhD in Life Science

MSc in Life Science

Tools

FACS

qPCR instruments

Imaging systems

Job description

Novartis in Cambridge, MA is seeking a senior scientist specializing in human immunology and immune profiling to lead immunology-focused studies on novel biotherapeutics, including AOCs and xRNA approaches.

You will design immune profiling assays, work with primary cells and multicolor FACS, generate mechanistic data for candidate optimization, and collaborate across disciplines to inform safety and translational strategies.