Senior Immunohistochemistry Scientist — Multiplex Imaging

AbbVie Inc.; Worcester (MA); Hybrid; USD 110,000 - 160,000; Full time

Benefits offered by this job

Benefits package

401(k)

Paid time off

Job summary

AbbVie is seeking an experienced immunohistochemistry scientist to join the Pathology team in a fast-paced drug discovery environment. You will design and execute single-plex and multiplex IHC and IF assays, collaborating with study pathologists and project teams to address target validation and expression questions.

You will optimize assays on Opal and Leica Bond Rx platforms, analyze data, and present clear findings with images and quantitative endpoints.

Qualifications

• Bachelor's or master's degree with relevant industry experience.
• Demonstrated experience performing immunohistochemistry and immunofluorescence assays.
• Strong knowledge of the Opal mIF platform, including assay development, optimization, and troubleshooting.
• Ability to work independently, prioritize workload, and manage multiple projects and deadlines.
• Excellent communication and collaboration skills.

Responsibilities

• Design and execute single-plex and multiplex IHC and IF assays.
• Partner with pathologists and project teams to determine assay design and approach.
• Develop, optimize, and troubleshoot assays using Opal and Leica Bond Rx.
• Analyze results and present findings with representative images and quantitative data.
• Provide technical leadership in IHC panel design and assay development.
• Apply image-analysis understanding to support the complete assay-development process.
• Mentor junior scientists and maintain compliant laboratory records.

Skills

Immunohistochemistry

Immunofluorescence

Image analysis

Independent work

Communication

MS Office

Education

Bachelor's degree in biology/chemistry or related field

Master's degree in biology/pathology/life sciences

Tools

Opal mIF platform

Leica Bond Rx

Sample Manager

DreamPath

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

Are you an experienced and motivated immunohistochemistry scientist looking to contribute to innovative drug discovery programs in a highly collaborative and dynamic environment? Join our Pathology team and help advance research that informs target validation, target distribution, animal model development, pharmacology, and combination therapy strategies.

The Pathology team is seeking an immunohistochemistry scientist to perform single-plex and multiplex immunohistochemistry and immunofluorescence assays using advanced multiplex immunofluorescence (mIF) platforms. The successful candidate will work closely with study pathologists, project teams, histotechnologists, and fellow scientists to develop robust assays and generate high-quality, quantitative data that support critical research decisions.

This role requires strong technical expertise, attention to detail, independent judgment, and the ability to manage multiple priorities in a fast-paced, team-oriented environment.

Key Responsibilities:

• Independently design and execute single-plex and multiplex immunohistochemistry and immunofluorescence assays ensure assay execution meets established quality and performance criteria
• Partner with pathologists and project teams to determine the most appropriate assay design and experimental approach for key project questions, including questions related to target validation and expression aligned with project objectives and timelines
• Develop, optimize, and troubleshoot assays using the Opal and Leica Bond Rx platforms with minimal input from pathologists
• Analyze results and present clear, well-organized findings with representative images and quantitative data
• Provide technical leadership in IHC panel design, assay optimization, and complex assay development
• Apply a thorough understanding of image analysis to support the complete assay-development process, from assay design through endpoint generation
• Mentor junior scientists and promote consistent, high-quality laboratory practices
• Evaluate emerging technologies and communicate relevant opportunities to the team
• Use Sample Manager, DreamPath, and other laboratory systems to document and track activities
• Maintain accurate, timely, and compliant experimental records

Qualifications

• Bachelor’s degree in biology/chemistry or related field with 10 years of experience or master’s degree with 8 years of experience
• Bachelor’s or master’s degree in biology, pathology, life sciences, or a related discipline, with relevant industry experience
• Demonstrated experience performing immunohistochemistry and immunofluorescence assays
• Thorough knowledge of the Opal mIF platform, including assay development, optimization, and troubleshooting
• Experience with image analysis and the ability to understand how image-analysis methods affect assay quality and quantitative endpoints
• Ability to work independently, prioritize workload, and manage multiple projects and deadlines
• Strong attention to detail and commitment to generating accurate, reproducible, and well-documented results
• Excellent communication and collaboration skills, including the ability to present technical findings clearly to cross-functional project teams
• Microsoft office skills

Preferred Qualifications:

• Qualification in IHC (QIHC)
• Experience with the COMET multiplex immunofluorescence platform
• Knowledge of spatial biology, quantitative pathology, or image-analysis software
• Familiarity with Sample Manager, DreamPath, or comparable laboratory tracking systems
• Experience mentoring junior scientists or providing technical guidance to colleagues
• This is an exciting opportunity to join a motivated and collaborative team of immunohistochemistry scientists and histotechnologists. If you enjoy solving technical challenges, applying emerging technologies, and working with multidisciplinary teams to advance drug discovery, we encourage you to consider joining us.

Other Desirable Attributes:

• Well organized
• Attention to detail
• Adherence to established protocols and laboratory documentation requirements
• Ability to work and effectively communicate within a team environment
• Ability to handle multiple projects simultaneously
• Delivery of high-quality, timely results
• Excellent oral and written communication skills
• Enthusiastic
• Independent, analytical, innovative thinker
• Proficiency with MS office-Excel, OneNote

Significant Work Activities and Conditions:

• Continuous standing for prolonged periods (more than 2 consecutive hours in an 8-hour day)
• Routine work with chemicals

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may bemodified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipate in our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremains in the Company'ssoleandabsolutediscretion unless and until paid andmay bemodified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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