Senior Genomics & ML Scientist - Onsite Cambridge

Net2Source (N2S); Cambridge (MA); On-site; USD 140,000 - 200,000; Full time

Job summary

Net2Source (N2S) invites applications for a Senior Bioinformatics Scientist III in Cambridge, MA. This 2-year contract role focuses on integrating human genetic data with multi-omics, applying ML to biomarker discovery and patient stratification, and supporting target identification.

The candidate will lead data ingestion, QC, imputation, GWAS/QTL analyses, and multi-omics integration using HPC and AWS, with emphasis on reproducibility and collaboration.

Qualifications

• Ph.D. in Genetics, Genomics, Statistical Genetics, Computational Biology, or a related field.
• A proven track record of over 5 years in genetic data analysis.
• Strong understanding of statistical methods and genetic data analysis and integration.
• Experience applying machine learning to high-dimensional biological data.
• Hands-on experience integrating multi-omics data with genetic data.
• Proficiency in R, Python, and Bash; reproducible analyses.
• Experience with HPC and AWS Cloud Computing.

Responsibilities

• Data Ingestion: query and harmonize external resources for genetic and multi-omics datasets.
• Genetic/Genomic Data Analysis: QC, imputation, variant calling and annotation.
• Statistical Genetics: GWAS/PheWAS, fine-mapping, colocalization, polygenic scores.
• QTL Analysis: eQTL, sQTL, pQTL mapping with tensorQTL/PLINK/R/qtl.
• Population Genetics Analysis: allele frequencies, LD, ancestry structure.
• Machine Learning: build/benchmark models for variant effect prediction and patient stratification.
• Multi-Omics Data Integration: integrate transcriptomics, proteomics, epigenomics with genetics.
• Documentation: reproducible workflows using Git, Nextflow, Snakemake.

Skills

R

Python

Bash

HPC

AWS

ML for genomics

Multi-omics integration

Statistical genetics

GWAS / QTL

Education

Ph.D. in Genetics

Tools

GATK

bcftools

samtools

ANNOVAR

VEP

PLINK

REGENIE

Job description

Net2Source (N2S) invites applications for a Senior Bioinformatics Scientist III in Cambridge, MA. This 2-year contract role focuses on integrating human genetic data with multi-omics, applying ML to biomarker discovery and patient stratification, and supporting target identification.

The candidate will lead data ingestion, QC, imputation, GWAS/QTL analyses, and multi-omics integration using HPC and AWS, with emphasis on reproducibility and collaboration.