Senior Bioinformatics Scientist - Genomics & ML

TALENT Software Services; Cambridge (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

TALENT Software Services is hiring a Contractor in Cambridge, MA for a Computational Precision Genetics team. You will apply ML to genetic and multi-omics data to support target identification, patient stratification, and biomarker discovery.

Strong programming in R, Python, and Bash is required, with HPC/AWS experience. The role focuses on integrating multi-omics, performing GWAS/QTL analyses, and delivering reproducible analyses in a collaborative environment.

Qualifications

• PhD in Genetics, Genomics, Statistical Genetics, Computational Biology, or related field.
• 5+ years of experience in genetic data analysis.
• Strong understanding of GWAS, QTL mapping, population genetics and genomic annotations.
• Experience applying ML to high‑dimensional biological data and avoiding confounding.

Responsibilities

• Data Ingestion: query and harmonize external resources for genetic and multi‑omics datasets.
• Genetic/Genomic Data Analysis: QC and analysis, variant calling and annotation.
• Statistical Genetics: GWAS/PheWAS, rare-variant tests, fine‑mapping, colocalization, polygenic scores, MR.
• QTL Analysis: identify loci for eQTL, sQTL, pQTL using tensorQTL, FastQTL, PLINK.
• Population Genetics Analysis: allele frequency, LD, ancestry structure.
• Machine Learning: develop/validate models for variant prediction and patient stratification.
• Multi‑Omics Data Integration: integrate transcriptomics, epigenomics, proteomics with genomic data.
• Documentation and Reproducibility: provide reproducible workflows (Git, Nextflow, Snakemake).

Skills

Genetic data analysis

Machine learning

Multi-omics data integration

R

Python

Bash

HPC

AWS

Communication

Education

PhD in Genetics/Genomics/Statistical Genetics

Tools

Nextflow

Snakemake

Docker

Singularity

GATK

PLINK

Seurat

Job description

TALENT Software Services is hiring a Contractor in Cambridge, MA for a Computational Precision Genetics team. You will apply ML to genetic and multi-omics data to support target identification, patient stratification, and biomarker discovery.

Strong programming in R, Python, and Bash is required, with HPC/AWS experience. The role focuses on integrating multi-omics, performing GWAS/QTL analyses, and delivering reproducible analyses in a collaborative environment.