Senior Full-Stack Engineer — AI Platform & LLM Systems

Protagonist Therapeutics; Washington (District of Columbia); On-site; USD 95,000 - 141,000; Full time

Job summary

Protagonist Therapeutics is hiring a Senior Full Stack Engineer (AI Platform) to build and evolve our internal AI-powered platform. You will own production systems end-to-end—from backend services and data infrastructure to analyst-facing applications—applying modern AI capabilities within a robust software platform.

The ideal candidate is a strong full-stack engineer with experience building AI-powered applications in production, comfortable across the stack, and ready to drive architectural

Qualifications

• Bachelor’s or master’s degree in Computer Science, Computer Engineering, or related field.
• 5+ years building production software with ownership of full-stack systems.
• Expert-level Python with Django and PostgreSQL experience.
• Strong TypeScript/React skills for data-heavy interfaces.
• Experience building LLM apps: agents, tool calling, RAG, prompt engineering.
• Experience with search infra (OpenSearch/Elasticsearch) and event-driven architectures.
• Hands-on with AWS, Docker, Kubernetes, Git, and CI/CD; Terraform familiarity.

Responsibilities

• Own features end-to-end across the platform: Django REST APIs, React UI, pipelines, and LLM services.
• Collaborate with leadership on architecture and roadmap; turn product vision into designs.
• Build LLM-powered systems on AWS Bedrock; develop cost/usage controls and tooling.
• Develop data and ML workflows in Metaflow on Argo/Kubernetes at scale.
• Design for the whole system: schema, indexing, event-driven processing, and API contracts.
• Work with customer-facing teams to translate needs into scalable software.
• Operate in sprints with the team, balancing multiple competing solutions.

Skills

Python

Django

PostgreSQL

TypeScript

React

AWS Bedrock

OpenSearch

Kubernetes

CI/CD

Terraform

Education

Bachelor's in CS/CE

Master’s degree

Tools

Metaflow

Argo Workflows

Docker

Terraform

Job description

Protagonist Therapeutics is hiring a Senior Full Stack Engineer (AI Platform) to build and evolve our internal AI-powered platform. You will own production systems end-to-end—from backend services and data infrastructure to analyst-facing applications—applying modern AI capabilities within a robust software platform.

The ideal candidate is a strong full-stack engineer with experience building AI-powered applications in production, comfortable across the stack, and ready to drive architectural