Senior Full-Stack Engineer

Simulations Plus, Inc.; United States; On-site; USD 120,000 - 170,000; Full time

Job summary

Simulations Plus, Inc. is a global leader in model-informed and AI-accelerated drug development.

The Senior Full-Stack Engineer will contribute across web/SaaS and AI/agents products, shipping features end-to-end on the stack (backend, frontend, and AI interfaces) within a lean, rapidly growing team. Reporting to the Product and Technology department, this role emphasizes building depth in web platform and applied AI engineering while supporting flexible, remote work arrangements and a strong,

Qualifications

• Bachelor's degree in CS, engineering, or related field.
• 3+ years of professional full-stack experience in production.
• Proficiency in JS/TS across Node.js and React.
• Experience with REST APIs and JSON.

Responsibilities

• Feature Delivery Across the Stack: Own features end-to-end across Node.js/Express backends and React/Tailwind frontends.
• AI Feature Integration: Integrate LLM-powered functionality into product surfaces with the AI lead.
• Team Impact: Contribute to code reviews, documentation, and engineering practices.
• Other Duties as Assigned: Support team goals and daily engineering work.

Skills

JavaScript/TypeScript

REST APIs

AI/Applied AI interest

AI coding tools (Claude, Cursor, Copil

Education

Bachelor's degree in Computer Science, Engineering, or related field

Tools

MongoDB

Node.js

React

Job description

Simulations Plus stands as a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions.

Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, annual bonus, and more! Check out how much our employees love working here: https://www.comparably.com/companies/simulations-plus.

Senior Full-Stack Engineer

The Senior Full-Stack Engineer is a versatile contributor, part of a small department whose charter spans both web/SaaS and AI/agents products. The role will ship features across the full stack — backend, frontend, and LLM-integrated surfaces — wherever the team's most pressing implementation work lands in a given cycle. It’s a high-variety role for an engineer who wants to build real depth across web platform and applied‑AI engineering, on a deliberately lean team that's growing quickly and intentionally.

Department: Product and Technology

Internal Grade: 10

Direct Reports: No

Status: Exempt

Location: Remote

Job Responsibilities

• Feature Delivery Across the Stack
  • Own features end-to-end across Node.js and Express backends and React/Tailwind frontends
  • Build the APIs, UI, and data flows behind real customer‑facing functionality
  • Contribute to the data, auth, and service patterns the platform builds on
• AI Feature Integration
  • Integrate LLM‑powered functionality into product surfaces, working alongside the team's AI lead
  • Wire frontends to LLM and MCP endpoints; handle streaming, errors, and degraded states gracefully
  • Contribute to evals, fixtures, and tooling that support the AI side of the team
• Team Impact
  • Bring full‑stack range to a team that values flexibility across backend, frontend, and AI
  • Contribute to code reviews, documentation, and the team's shared engineering practices
  • Apply AI coding tools effectively as part of daily engineering workflow
• Other Duties as Assigned

Required Qualifications

• 3+ years of professional software engineering experience, with shipped full‑stack work in production
• Proficiency in JavaScript or TypeScript across Node.js backend and React frontend
• Practical experience with document or NoSQL databases such as MongoDB
• Comfort building and consuming REST APIs and JSON contracts
• Genuine interest in agents, MCP, and applied AI, and the drive to build real expertise in those areas
• Fluency using AI coding tools (Claude, Cursor, Copilot) in daily workflow

Preferred Qualifications

• Familiarity with Anthropic, OpenAI, or other LLM provider SDKs
• Exposure to MCP, agent frameworks, or LLM‑integrated product features
• Experience with cloud infrastructure (AWS preferred) and CI/CD pipelines
• Experience in regulated‑software environments (SOC 2, HIPAA, GxP, 21 CFR Part 11) or life‑sciences SaaS
• Familiarity with Passport, OAuth, OIDC, or comparable auth patterns

Education

• Bachelor's degree in computer science, engineering, or related field preferred
• Relevant technical certifications welcomed