Senior Software Engineer Full-stack

HealthX Ventures; San Francisco (CA); On-site; USD 120,000 - 190,000; Full time

Job summary

InsightRX is seeking a Full Stack Engineer to help build the Astra AI platform, merging a modern web app with conversational AI agents for PK/PD analysis and clinical trial data workflows.

You will work across client, server, and agent layers, shaping how the frontend talks to the API, how queues track work, and how LLM-powered agents process data and return results.

Qualifications

• Experience building production-grade full-stack web apps across client and server layers.
• Strong TS skills on frontend and backend (React + Node/NestJS).
• Experience designing REST APIs and relational data models.

Responsibilities

• Build and maintain features across React TS client and NestJS TS backend.
• Design client-server architecture: state management, routing, authentication (SSO/SAML), real-time updates (WebSockets).
• Collaborate on integration between web app and LLM-based agents.
• Work with agents for PK/PD analysis workflows and data quality checks.
• Contribute to database schema design and migrations (PostgreSQL/Sequelize).
• Participate in code reviews, architecture discussions, and production support.

Skills

TypeScript

React

NestJS

REST APIs

PostgreSQL

MongoDB

SSO/SAML

AWS SQS

LLM integration

Testing (Jest/pytest)

Tools

Swagger

WebSockets

Sequelize

Job description

InsightRX | Engineering

About the Role

InsightRX is looking for a Full Stack Engineer to help build our Astra AI platform — a system that combines a modern web application with conversational AI agents to support pharmacokinetic/pharmacodynamic (PK/PD) analysis and clinical trial data workflows. You'll work across the client, server, and agent layers, understanding how they fit together end to end: how the frontend talks to the API, how the API queues and tracks work, and how LLM-powered agents process data and return results.

This is a strong fit for someone who enjoys working across the stack, is comfortable navigating both traditional web application architecture and newer LLM-agent design patterns, and wants to build tools used directly in pharmaceutical R&D decision-making.

What You'll Work On

• Build and maintain features across our React/TypeScript client and NestJS/TypeScript backend, including UI components, REST APIs, and the data layer connecting them.
• Design and extend the client-server architecture: state management, routing, authentication (including SSO/SAML), real-time updates via WebSockets, and background job processing via AWS SQS.
• Collaborate on the integration layer between the web app and our LLM-based agents — message schemas, queue-based communication, and file/data handoff.
• Work with our conversational AI agent system, which orchestrates multiple specialized agents for statistical modeling, data quality checks, and PK/PD analysis workflows.
• Contribute to database schema design and migrations (PostgreSQL/Sequelize), API documentation (Swagger), and test coverage (Jest, pytest).
• Participate in code review, architecture discussions, and production support across the stack.

What We're Looking For

• Strong professional experience building production level full stack web applications, comfortable owning features from database to UI.
• Strong TypeScript skills across both frontend (React) and backend (Node.js/NestJS) contexts.
• Experience designing REST APIs, relational data models (PostGresSQL, MongoDB), and authentication/authorization flows.
• Familiarity with message-queue or event-driven architectures (SQS, similar).
• Comfort reading and reasoning about systems that integrate with LLMs — understanding agent/tool patterns, prompt-driven workflows, and the practical quirks of working with LLM output, even without deep AI/ML research background.
• Strong problem-solving, ownership, and ability to debug across web applications and nondeterministic AI behavior.
• Uses Claude Code, Codex, or similar AI coding tools effectively while understanding, validating, and taking responsibility for the resulting code.
• Good instincts for reliability and correctness in domains where data quality matters — you ask "what happens when this fails or the data is malformed."
• Clear communicator, comfortable working across an evolving codebase with detailed technical documentation.
• Operate with a high level of independence and cope with ambiguity

Nice to Have

• Experience with LLM agent architecture a plus
• Experience with SAML SSO, multi-tenant systems, or healthcare/life-sciences software.