Senior Formulation Scientist Preclinical Drug Development

Septerna; South San Francisco (CA); On-site; USD 160,000 - 180,000; Full time

Benefits offered by this job

Benefits

Stock options

Annual bonus

Job summary

Septerna, based in South San Francisco, CA, seeks a Staff Scientist in Pharmaceutical Development to advance small molecule formulation programs across preclinical studies. The role emphasizes designing, executing, and delivering fit-for-purpose formulations for nonclinical DMPK, pharmacology, and toxicology studies.

The candidate will collaborate with cross-functional teams, prepare technical documentation, and manage multiple priorities in a fast-paced environment, reporting to the Director of

Qualifications

• PhD/MS/BS in a related field with industry experience in small molecule formulation development.
• Proven ability to translate data into formulation strategies for preclinical studies.
• Experience in multiple routes of administration and solid dosage forms.
• Hands-on analytical skills with UPLC/HPLC and solid-state characterization.
• Knowledge of regulatory guidance and working with external CDMOs/CROs.
• Strong written and oral communication with data integrity and teamwork.

Responsibilities

• Develop early formulation strategies to support PK, PD, efficacy and safety preclinical studies.
• Design and execute early formulation screening to enable high-quality in vivo data.
• Implement workflows and collaborate with CDMOs/CROs for preclinical studies.
• Represent early formulation on cross-functional teams with data-driven recommendations.
• Author and review technical documents for early formulation activities and studies.
• Manage multiple priorities to ensure timely supply of formulations.

Skills

Formulation development

Data analysis

Scientific communication

Education

PhD in Pharmaceutics

MS in Pharmaceutical Sciences

BS in Chemical Engineering

Tools

UPLC/HPLC

XRPD

DSC

DVS

PLM

Particle size analysis

Solid-state analysis

Job description

Septerna, based in South San Francisco, CA, seeks a Staff Scientist in Pharmaceutical Development to advance small molecule formulation programs across preclinical studies. The role emphasizes designing, executing, and delivering fit-for-purpose formulations for nonclinical DMPK, pharmacology, and toxicology studies.

The candidate will collaborate with cross-functional teams, prepare technical documentation, and manage multiple priorities in a fast-paced environment, reporting to the Director of