Senior DMPK Scientist — LC-MS/MS & Bioanalysis

Revolution Medicines, Inc.; San Francisco (CA); On-site; USD 106,000 - 126,000; Full time

Benefits offered by this job

Equity awards

Strong benefits

Learning & development opportunities

Job summary

Revolution Medicines, Inc. is seeking a skilled DMPK laboratory scientist to develop LC-MS/MS methods and analyze in vivo and in vitro samples supporting ADME and pharmacokinetic studies.

You will handle tumor tissues and various matrices, perform data analysis, and maintain LC-MS/MS instruments in a dynamic NDCP environment. The role requires 3–5+ years of industry experience with LC-MS/MS, HPLC/UPLC method development, and strong organizational skills in a fast-paced team setting.

Qualifications

• Bachelor’s or master’s degree in pharmaceutical sciences or related field with 5+ years (BS) or 3+ years (MS) in industry.
• Hands-on experience operating and maintaining LC-MS/MS systems.
• LC-MS/MS method development and bioanalytical analysis experience.
• Knowledge of biological sample preparation and extraction for LC-MS/MS.
• Hands-on experience in HPLC/UPLC method development.
• Ability to customize and follow established assay protocols.
• Ability to manage multiple lab and project tasks efficiently.
• Team-oriented, flexible and highly organized with good record-keeping.
• Adaptable in a fast-paced environment.

Responsibilities

• Develop LC-MS/MS methods and analyze samples for ADME, PK, efficacy, and toxicokinetic studies.
• Handle tissues including tumors from homogenization to bioanalysis prep.
• Perform data analysis, prepare result reports, and upload data to electronic notebooks.
• Conduct in vitro ADME/DMPK assays in matrices (hepatocytes, microsomes, blood, plasma).
• Support lab operations, including safety, LC-MS/MS instrument maintenance and troubleshooting.

Skills

LC-MS/MS operation

LC-MS/MS method development

Bioanalytical analysis

Sample preparation techniques

HPLC/UPLC method development

Follow established protocols

multitasking across labs

Team-oriented & adaptable

Record-keeping skills

Education

Bachelor’s or Master’s in pharmaceutical sciences (5+ years with BS or 3+ years with MS)

Relevant industry experience

Tools

SCIEX QTRAP MS

Job description

Revolution Medicines, Inc. is seeking a skilled DMPK laboratory scientist to develop LC-MS/MS methods and analyze in vivo and in vitro samples supporting ADME and pharmacokinetic studies.

You will handle tumor tissues and various matrices, perform data analysis, and maintain LC-MS/MS instruments in a dynamic NDCP environment. The role requires 3–5+ years of industry experience with LC-MS/MS, HPLC/UPLC method development, and strong organizational skills in a fast-paced team setting.