DMPK Scientist: LC-MS Bioanalysis & PK

Zealand Pharma U.S., Inc.; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Zealand Pharma U.S., Inc. in Cambridge, MA is expanding its Global DMPK group and seeks a scientist with hands-on LC-MS bioanalysis and DMPK expertise to advance complex molecule modalities.

The role covers method development, PK study design, and data interpretation, with emphasis on bioanalysis of peptides, antibodies, and conjugates, and collaboration across Discovery, Translational, and Regulatory teams.

Qualifications

• PhD in pharmaceutical sciences, biochemistry, analytical chemistry, chemistry or a related scientific field with 0-3 years of relevant industry or postdoctoral experience.
• M.S. with approximately 3-6 years of relevant industry experience.
• B.S./B.A. with approximately 5-8+ years of relevant industry experience.
• Solid hands-on background in LC-MS bioanalysis and assay development.
• Experience in PK study design, data interpretation, and translating DMPK insights into actionable project recommendations is an advantage.
• Experience with bioanalysis of complex molecules such as peptides, antibodies and conjugates is an advantage.
• Familiarity with ADME assays and metabolite ID for larger molecules, as well as experience with digital/automation-enabled bioanalysis and DMPK workflows, is an advantage.

Responsibilities

• Contribute to the development of DMPK discovery platforms and bioanalysis capabilities for complex drug modalities (e.g., antibodies, antibody‑peptide conjugates and peptides).
• Execute the LC-MS bioanalysis workflow, from input to PK study design to method development, sample analysis and reporting of PK and exposure data.
• Support PK and metabolite identification across discovery projects.
• Design and conduct in‑vitro assays, such as metabolic stability experiments or other project‑relevant DMPK assays.
• Contribute to continuous improvement by adopting efficient, digital and automation‑enabled approaches within DMPK workflows.

Skills

LC-MS bioanalysis

DMPK knowledge

Analytical chemistry

Bioanalysis of complex molecules

Education

PhD in pharmaceutical sciences / biochemistry / analytical chemistry

MS with 3–6 years experience

BS/BA with 5–8+ years experience

Tools

LC-MS instrumentation

Bioanalysis software

Job description

Zealand Pharma U.S., Inc. in Cambridge, MA is expanding its Global DMPK group and seeks a scientist with hands-on LC-MS bioanalysis and DMPK expertise to advance complex molecule modalities.

The role covers method development, PK study design, and data interpretation, with emphasis on bioanalysis of peptides, antibodies, and conjugates, and collaboration across Discovery, Translational, and Regulatory teams.