Senior Discovery Scientist, Membrane Proteins

Altos Labs; Redwood City (CA); On-site; USD 156,000 - 221,000; Full time

Job summary

Altos Labs is seeking a Scientist in Discovery Science (Bay Area campus) to advance programs on brain aging and neurodegeneration using lipid and protein biochemistry. You will design constructs, express and purify membrane-associated proteins, and perform comprehensive biophysical characterization.

The role requires a PhD in a related field, strong collaboration, and experience with membrane protein purification, crystallography or cryo-EM workflows, and binding biophysics.

Qualifications

• PhD in Biochemistry, Chemistry, Biophysics, or Structural Biology.
• Demonstrable understanding of biochemistry, including EM for structural biochemistry.
• Excellent communication and collaboration within a dynamic team.
• Experience with quantitative binding biophysics (BLI, SPR, or ITC), including kinetics/affinity analysis.
• Experience with assessing purity, mass, or stability (mass photometry, SEC-MALS, DLS, analytical SEC, or DSF/thermal stability).
• Experience reconstituting membrane or lipid-associated proteins into liposomes or nanodiscs.
• Experience with Cryo-EM sample prep and data analysis workflows.
• High rigor in experimental design, data recording, and ELN documentation.
• Proactive, problem-solving attitude; ability to manage multiple priorities and meet timelines.

Responsibilities

• Design expression constructs and perform recombinant cell culture for membrane protein purification.
• Evaluate purity, stability, and physical properties of purified proteins.
• Develop new protein activity assays and establish SOPs.
• Coordinate with CROs for material generation and analysis.

Skills

Membrane protein purification

Biophysical analysis

Cryo-EM workflows

Mass spectrometry

X-ray crystallography

ELN documentation

Collaboration

Protein expression (mammalian)

Education

PhD in Biochemistry, Chemistry, Biophysics, or Structural Biology

Tools

Cryo-EM

Mass spectrometry

NMR

X-ray crystallography

Job description

Altos Labs is seeking a Scientist in Discovery Science (Bay Area campus) to advance programs on brain aging and neurodegeneration using lipid and protein biochemistry. You will design constructs, express and purify membrane-associated proteins, and perform comprehensive biophysical characterization.

The role requires a PhD in a related field, strong collaboration, and experience with membrane protein purification, crystallography or cryo-EM workflows, and binding biophysics.