Senior Discovery Chemist — Lead Therapeutics Innovation

BeOne Medicines; San Carlos (CA); On-site; USD 165,000 - 207,000; Full time

Job summary

BeOne Institute in San Carlos, CA is seeking a Principal Scientist to lead end-to-end chemistry efforts for exploratory research on novel modalities and screening technologies. The role emphasizes innovative problem solving, scalable synthetic routes, and collaboration with cross-functional teams to advance BeOne’s therapeutic programs.

The ideal candidate holds a Ph.D. in organic/medicinal chemistry with 6+ years’ experience in drug discovery, a strong track record in library design, SAR-driven

Qualifications

• Ph.D. or equivalent in organic/medicinal chemistry with 6+ years of research.
• Deep expertise in synthetic organic chemistry for drug discovery.
• Design and synthesize diverse libraries to probe SAR.
• Proficient in parallel, convergent, and modular synthesis strategies.
• Ability to independently develop synthetic routes for new chemical matter.
• Strong communication and presentation skills for technical audiences.

Responsibilities

• Lead chemistry initiatives to explore innovative modalities and screening strategies.
• Design and implement diverse compound libraries to test SAR hypotheses.
• Develop parallel synthesis techniques for rapid library creation.
• Devise and refine synthetic pathways for diversification and scalability.
• Apply SAR insights to guide compound optimization.
• Communicate progress and collaborate with cross-disciplinary teams.
• Support BeOne Institute strategic objectives at the San Carlos site.
• Manage external chemistry teams.

Skills

Synthetic organic chemistry

Library design & synthesis

Parallel/convergent synthesis

Drug discovery experience

Communication skills

Leadership

Education

Ph.D. in Organic/Medicinal Chemistry

Tools

CADD tools

Molecular docking

Spotfire

Job description

BeOne Institute in San Carlos, CA is seeking a Principal Scientist to lead end-to-end chemistry efforts for exploratory research on novel modalities and screening technologies. The role emphasizes innovative problem solving, scalable synthetic routes, and collaboration with cross-functional teams to advance BeOne’s therapeutic programs.

The ideal candidate holds a Ph.D. in organic/medicinal chemistry with 6+ years’ experience in drug discovery, a strong track record in library design, SAR-driven