Senior Director, Statistical Innovation & Biostatistics

Alnylam Pharmaceuticals; Philadelphia (Philadelphia County); Hybrid; USD 247,000 - 334,000; Full time

Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

401(k) match

Wellness days

Recharge breaks

Family resources

Job summary

Alnylam Pharmaceuticals seeks a Senior Director Biostatistics, Head of Statistical Innovation & Methodology to lead advanced statistical methods, trial design, and simulation-based approaches across clinical development. You will shape strategies and act as an internal expert guiding project teams.

Reporting to the Head of Biostatistics, you will mentor statisticians, collaborate with cross-functional teams, and engage with regulatory agencies and external partners to advance methodological

Qualifications

• PhD in statistics/biostatistics or related quantitative discipline.
• 12+ years in pharma/biotech with statistical innovation experience.
• Expertise in clinical trial design and modern statistical methods.

Responsibilities

• Lead innovative statistical methodologies for clinical programs.
• Oversee methodological research and tool development for practical use.
• Provide expert statistical consultation to development teams.
• Shape strategies for trial design, analysis, and decision frameworks.
• Mentor statisticians and grow a regional innovation team.
• Engage regulators and academic partners on methodological advances.

Skills

Clinical trial design

Bayesian methods

Model-based decision frameworks

Statistical leadership

Mentor statisticians

Education

PhD in Statistics/Biostatistics

Job description

Alnylam Pharmaceuticals seeks a Senior Director Biostatistics, Head of Statistical Innovation & Methodology to lead advanced statistical methods, trial design, and simulation-based approaches across clinical development. You will shape strategies and act as an internal expert guiding project teams.

Reporting to the Head of Biostatistics, you will mentor statisticians, collaborate with cross-functional teams, and engage with regulatory agencies and external partners to advance methodological