Senior Director, Scientific Computing & AI Platform

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 159,000 - 207,000; Full time

Benefits offered by this job

401(k)

Healthcare coverage

Employee Stock Purchase Plan

Job summary

Denali Therapeutics Inc is looking for a senior platform engineer in South San Francisco specializing in scientific computing and AI solutions. Responsibilities include leading HPC cluster architecture, collaborating with research scientists to optimize workflows, and designing production AI systems.

The ideal candidate has over 10 years of related experience, significant expertise in HPC optimization, and strong skills in Python. A competitive salary range of $159,000 to $207,000 is offered, along with a comprehensive benefits package.

Qualifications

• 10–12+ years of experience in platform engineering or scientific computing.
• At least 3 years at a senior/principal individual-contributor level.
• Deep expertise in HPC cluster optimization and AI/ML platform engineering.

Responsibilities

• Lead the architecture and optimization of on-premise GPU clusters.
• Collaborate with research scientists to improve job performance.
• Design production AI/ML systems and generative AI solutions.

Skills

HPC cluster administration and optimization

Cloud platform engineering

AI/ML platform engineering

Python scripting

Infrastructure as Code

Education

Bachelor’s or Master’s degree in Computer Science or Engineering

Tools

Slurm/LSF

GPU/CUDA environments

Vector databases

Job description

Denali Therapeutics Inc is looking for a senior platform engineer in South San Francisco specializing in scientific computing and AI solutions. Responsibilities include leading HPC cluster architecture, collaborating with research scientists to optimize workflows, and designing production AI systems.

The ideal candidate has over 10 years of related experience, significant expertise in HPC optimization, and strong skills in Python. A competitive salary range of $159,000 to $207,000 is offered, along with a comprehensive benefits package.