Senior Director, Scientific Computing & AI Platform

Denali Therapeutics; South San Francisco (CA); On-site; USD 159,000 - 207,000; Full time

Benefits offered by this job

401k

Healthcare coverage

Employee Stock Purchase Plan (ESPP)

Job summary

Denali Therapeutics in South San Francisco seeks a Scientific Computing and AI Engineer to architect and optimize GPU clusters and cloud HPC systems. This role bridges engineering with scientific impact, ensuring robust production-grade platforms for drug discovery.

Ideal candidates will have over 10 years of experience in platform engineering, specializing in HPC optimization and AI workflows. Denali offers a competitive salary range of $159,000 to $207,000 along with a comprehensive benefits package.

Qualifications

• Typically 10-12+ years of experience in platform engineering with 3 years at a senior level.
• Deep expertise in HPC cluster administration, cloud platform engineering, and generative AI.
• Experience in regulated biotech or pharmaceutical environments with exposure to GxP.

Responsibilities

• Lead architecture and optimization of GPU clusters and HPC environments.
• Design and support compute environments for intensive workloads like molecular dynamics.
• Mentor and develop engineers across the organization.

Skills

HPC cluster administration and optimization

AI/ML platform engineering

Cloud platform engineering

Python and scripting skills

Education

Bachelor’s or Master’s degree in Computer Science or Engineering

Tools

Slurm

CUDA

Infrastructure as Code tooling

CI/CD pipelines

Job description

Denali Therapeutics in South San Francisco seeks a Scientific Computing and AI Engineer to architect and optimize GPU clusters and cloud HPC systems. This role bridges engineering with scientific impact, ensuring robust production-grade platforms for drug discovery.

Ideal candidates will have over 10 years of experience in platform engineering, specializing in HPC optimization and AI workflows. Denali offers a competitive salary range of $159,000 to $207,000 along with a comprehensive benefits package.