Senior Director, Oncology Clinical Science Strategy

CytomX Therapeutics, Inc.; Emeryville (CA); Hybrid; USD 260,000 - 330,000; Full time

Job summary

CytomX Therapeutics, Inc. is seeking a Senior Director, Clinical Science to provide strategic and scientific leadership for oncology programs from early to late-stage development.

You will translate safety, efficacy, pharmacology, biomarker, and operational data into actionable recommendations that shape clinical strategy and study execution. Your role includes leading integrated data reviews, guiding study design and execution, and mentoring colleagues while collaborating across Therapeutics,

Qualifications

• MD, PharmD, PhD, or an equivalent advanced degree in medicine, pharmacy, life sciences, or a related discipline.
• At least 10 years of relevant biotechnology or pharmaceutical industry experience, including at least 7 years of direct clinical-development experience.
• Clinical-development experience in oncology and with design, execution, analysis, and interpretation of interventional studies.
• Ability to lead complex clinical-science deliverables and influence multidisciplinary stakeholders.

Responsibilities

• Provide scientific leadership for design, execution, interpretation, and communication of clinical studies across Phase 1–3 oncology programs.
• Lead development and review of protocols, investigator materials, clinical study reports, regulatory content, and internal materials.
• Integrate efficacy, safety, pharmacokinetic, pharmacodynamic, biomarker, and operational data to guide strategy.
• Lead ongoing clinical data review in collaboration with Clinical Operations and other functions.
• Develop clear, scientifically grounded recommendations on study design, endpoints, and development options.
• Serve as senior Clinical Science representative on study and program teams.
• Support interactions with investigators, regulators, and external partners as appropriate.
• Communicate complex information clearly to executives, governance bodies, and investigators.

Skills

Clinical leadership

Cross-functional collaboration

Data interpretation

Regulatory science

Education

MD or MD/PhD

PhD in life sciences

Tools

Regulatory documentation tools

Job description

CytomX Therapeutics, Inc. is seeking a Senior Director, Clinical Science to provide strategic and scientific leadership for oncology programs from early to late-stage development.

You will translate safety, efficacy, pharmacology, biomarker, and operational data into actionable recommendations that shape clinical strategy and study execution. Your role includes leading integrated data reviews, guiding study design and execution, and mentoring colleagues while collaborating across Therapeutics,