Senior Director, Evidence Generation

Xeris Pharmaceuticals, Inc.; Chicago (IL); Hybrid; USD 252,000 - 337,000; Full time

Job summary

Xeris Pharmaceuticals, Inc. is searching for a Senior Director of Evidence Generation to lead real-world evidence strategies across its commercial and investigational pipeline. You will develop and execute integrated evidence generation plans while collaborating closely with the Medical Affairs team.

The ideal candidate has over 12 years of experience in HEOR and a strong background in health economics or outcomes research. This hybrid position based in Chicago requires at least three days of work in the office each week.

Qualifications

• 12+ years of experience in HEOR, outcomes research, or market access.
• Demonstrated expertise in health economics and real-world evidence.
• Proven track record of scientific publications in peer-reviewed journals.

Responsibilities

• Lead the development of evidence generation strategies across the product lifecycle.
• Oversee health economics, outcomes research, and evidence initiatives.
• Collaborate with Medical Affairs and external partners on evidence needs.

Skills

Health Economics

Outcomes Research

Biostatistics

Analytical Skills

Project Management

Education

PhD, DrPH, ScD, PharmD, MD in relevant fields

Job description

Job Description

The Senior Director, Evidence Generation will serve as the lead of real‑world evidence generation strategy, execution, and partnership across the Xeris commercial and investigational pipeline. Reporting to the VP, Medical Affairs, this strategic leader defines, develops, and executes integrated evidence generation strategies that demonstrate clinical, economic, and humanistic value of the company's therapies across the product lifecycle. The role provides scientific, analytical, and operational leadership for health economics, outcomes research, real‑world evidence (RWE), patient‑reported outcomes (PRO), and comparative effectiveness research initiatives that support market access, reimbursement, regulatory, and clinical decision‑making.

Essential Job Functions

• Develop and execute integrated HEOR and evidence generation strategies and plans across product lifecycle, including portfolio planning and life‑cycle management activities
• Foster a culture of scientific excellence, innovation, collaboration, and continuous improvement
• In partnership with Medical Affairs Leadership, define the vision, structure, and capabilities of the Evidence Generation team for future state
• Identify evidence gaps and prioritize studies to support payer, provider, institution, and patient‑level decision‑making
• Provide HEOR input into clinical development programs, including endpoint selection and evidence planning
• Lead development of economic models, budget impact analyses, cost‑effectiveness studies, and value dossiers
• Oversee generation of comparative effectiveness and burden‑of‑illness evidence
• Guide development of patient‑reported outcomes and health‑related quality‑of‑life research programs
• Ensure methodological rigor and scientific validity across all real‑world evidence initiatives
• Ensure projects, initiatives, and analyses align with medical and brand strategic plans with cross‑functional alignment
• Evaluate and acquire novel data sources to generate actionable evidence
• Oversee retrospective database analyses, pragmatic trials, and outcomes research studies in partnership with Medical and Scientific Leads and/or external subject‑matter experts
• Establish and maintain relationships with external researchers, healthcare decision‑makers, and evidence‑generation partners
• Responsible for strategic and timely communications on execution of plans internally and externally, leading to successful completion and data disclosure
• Oversee external vendors and partnerships to ensure high‑quality, high‑impact, robust outputs
• Collaborate with Publications and Medical Communications on timely communication and publication of research
• Accountable for end‑to‑end delivery of the HEOR book of work, from strategy development to content pull‑through
• Ensure strong partnership with all relevant HEOR COE functions to represent a comprehensive HEOR voice in cross‑functional meetings

Skills And Qualifications

• PhD, DrPH, ScD, PharmD, MD, or equivalent advanced degree in Health Economics, Outcomes Research, Epidemiology, Public Health, Health Services Research, Biostatistics, Pharmacy, Medicine, or related discipline
• Demonstrated scientific and technical expertise in health economics, pharmacoepidemiology, biostatistics, or real‑world evidence research
• 12+ years of experience in HEOR, outcomes research, epidemiology, market access, or evidence generation within the pharmaceutical, biotechnology, consulting, or healthcare industry
• Experience supporting payer engagement and reimbursement strategy
• Track record of scientific publications and presentations in peer‑reviewed journals and major congresses

Technical Competencies

• Health economics modeling and value assessment
• Real‑world evidence strategy and execution
• Comparative effectiveness research
• Patient‑reported outcomes and quality‑of‑life measurement
• Epidemiology and observational study design
• Market access and reimbursement strategy
• Health technology assessment requirements
• Evidence synthesis and systematic literature reviews
• Data analytics and healthcare databases
• Scientific communications and publication planning

Competencies

• Teamwork & collaboration
• Attention to detail
• Self‑starter
• Analytical skills
• Negotiation skills
• Problem solving
• Organizational skills
• Project management
• Adaptability
• Professionalism
• Written and verbal communications
• Presentation skills
• Strategic leadership
• Functional leadership
• Strategic vision

Working Conditions

• Position may require periodic evening and weekend work, as well as periodic overnight travel
• Position may require both vehicle and air travel
• This is a hybrid role based in Xeris' Chicago office and requires a minimum of three days per week in the office; the on‑site requirement may change at management's discretion

The anticipated base salary range for this position is $252,000-$337,000.

Equal Opportunity Employer

Xeris Pharmaceuticals, Inc. (the 'Company') is an equal‑opportunity employer and does not discriminate based on race, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, veteran status, genetics or any other characteristic protected by law. All qualified candidates are given equal opportunity and the Company’s employment selection decisions are based solely on job‑related factors. NOTE: This job description is not intended to be all‑inclusive. The employee may be required to perform other related duties as needed to meet the ongoing needs of the Company.