Senior Director, Commercial Forecasting & Artificial Intelligence

Immatics; Houston (TX); Remote; USD 240,000 - 280,000; Full time

Benefits offered by this job

Health insurance

Dental insurance

Vision insurance

Vacation 4 weeks

Holidays 12

Sick leave 7 days

Life insurance

Disability coverage

401(k) with company match

Parental leave

Voluntary benefits

Job summary

Immatics is seeking a Senior Director, Commercial Forecasting & AI to lead demand, revenue and patient-flow forecasting across the portfolio while serving as the in-house AI expert for the Commercial organization.

The role reports to the VP Commercial Analytics & Operations and is location-flexible as Remote U.S. Travel 10-15% is required. Salary ranges from $240,000 to $280,000 with comprehensive benefits and a strong emphasis on AI-enabled decision support.

Qualifications

• Bachelor’s degree or equivalent experience in life sciences or related field.
• 15+ years in life sciences consultancy, biotech, pharma or related.
• Forecasting experience in oncology or cell/gene therapy preferred.

Responsibilities

• Develop Commercial AI roadmap across Marketing, Market Access and Field Operations with clear business impact.
• Design and implement AI-powered systems to automate recurring analytics and forecasting tasks.
• Evaluate AI platforms, run pilots, and make build-versus-buy recommendations.

Skills

Forecasting

Commercial analytics

AI in life sciences

Python

SQL

Power BI/Tableau

Excel modelling

Epidemiology data

KOL intelligence

Education

Bachelor’s degree

Tools

IQVIA

Symphony Health

Komodo

Definitive Healthcare

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

We are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient-flow forecasting across Immatics' portfolio - from early pipeline opportunity assessment through launch readiness and in-line performance. The other half is serving as the Commercial organization’s in-house AI expert: identifying, building and scaling AI and generative-AI capabilities that make a small commercial team perform like a much larger one. The successful candidate is a recognized forecasting expert in oncology or cell and gene therapy who has already put AI to practical, compliant use in a life sciences commercial setting.

Reports to: VP Commercial Analytics & Operations

Location: Remote U.S.

Salary Range: $240,000 – $280,000

Basic Qualifications

• Bachelor’s or equivalent years of experience
• 15+ years in Life sciences consultancy, biotech, pharma or related

Preferred Qualifications:

• 7 Years of Forecasting, Commercial Analytics or market insights
• Demonstrated expertise building patient-based and epidemiology-driven forecast models from the ground up for both pre-launch and in-line assets.
• Deep working knowledge of pharma/biotech data sources and their strengths and limitations - e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research.
• Demonstrated, hands-on experience applying AI and large language models to real commercial problems in a regulated life sciences environment - including practical fluency with LLM platforms, prompt engineering, retrieval-augmented generation and agentic workflows, and a clear-eyed view of where AI does and does not work.
• Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation).
• Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau).
• Experience across the launch lifecycle in oncology, cell and gene therapy, rare disease or another specialty/limited-distribution setting.
• Proven ability to operate independently in a lean, fast-moving environment, and to translate complex quantitative and technical work into decision-ready recommendations for senior stakeholders.
• Direct experience forecasting an autologous CAR-T, TCR-T or other engineered cell therapy asset, including site activation and manufacturing-constrained demand models.
• Track record of standing up a forecasting or commercial AI capability at a pre-commercial or newly commercial company.
• Exposure to global forecasting and to market access/pricing analytics in specialty oncology.

In This Role You Will

• Develop Commercial AI roadmap - Serve as the Commercial team's resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high-value AI and generative-AI use cases - analytics and forecasting, market research synthesis, competitive intelligence, field enablement, content development and promotional review preparation, account and KOL intelligence, payer and policy monitoring, and CRM data quality - with a clear view of business impact, effort and sequencing.
• Build the operating systems - Design, build and own AI-powered systems that become how Commercial runs day to day - not one-off pilots. Re-engineer the analytics workflow end to end so recurring work runs itself: automated ingestion and QC of claims, specialty distributor, CRM and third-party data; reconciliation and exception flagging; forecast and dashboard refreshes; self-service analytics layers; recurring report and insight generation; and agentic workflows that take manual assembly off the critical path - shifting the team's time from producing numbers to interpreting them.
• Build vs. buy and vendors - Evaluate AI platforms and vendors, run structured pilots against defined success criteria, and make defensible build-versus-buy recommendations.

Travel Requirements

• 10-15%

What do we offer?

At Immatics, we believe in investing in our team's health, safety and well-being. Here's what you can expect if you join Immatics

Comprehensive Benefits

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insuranceup to at 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short-and long-Term disability coverage
• 401(k) with immediate eligibilityand company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
• Partially paid parental leavefor eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard torace, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexualorientation, gender identity or expression, national origin, ancestry, age, marital status, disability, geneticinformation, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely heldreligious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at [e-mail].

Work Authorization

Applicants must be authorized to work in the United States without the need for current or future sponsorship.

Pre-Employment Requirements

Employment is contingent upon successful completion of a background check, referencechecksand pre-employment drug screening, wherepermittedby applicable law. For certain roles, additionalscreenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.