Senior Director, Clinical Pharmacology & Pharmacometrics

BridgeBio; San Francisco (CA); Hybrid; USD 265,000 - 289,000; Full time

Benefits offered by this job

Hybrid work model

ESPP

Health benefits

401(k) with employer match

Job summary

BridgeBio in San Francisco seeks a Senior Director, Clinical Pharmacology to lead pharmacology strategies across clinical programs and PK/PD modeling. This hybrid, cross‑functional role focuses on external CRO oversight and regulatory interactions.

The position requires 10+ years in biotech/pharma, strong modeling expertise, and experience in pediatric development where possible. BridgeBio offers a competitive compensation package and comprehensive benefits.

Qualifications

• 10+ years in biotechnology/pharmaceutical industry in clinical pharmacology.
• Strong track record in population PK, PK/PD, PBPK and modeling.
• Experience in pediatric drug development is preferred.

Responsibilities

• Develop and implement clinical pharmacology and pharmacometrics strategies across all stages of clinical development, including pediatric programs.
• Manage design and application of NCA, population PK, exposure–response, PK/PD, and PBPK models to inform decisions.
• Oversee modeling and simulation analyses to support dose selection and study design for pediatric trials and regulatory submissions.
• Author clinical pharmacology sections of regulatory documents and support interactions with global regulators.
• Design studies and manage CROs, conduct PK data analyses, and approve reports.
• Present results to internal teams and external stakeholders and contribute to publications and conferences.

Skills

Population PK

PK/PD

PBPK

Pediatric development

Quantitative data analysis

Education

PhD or PharmD in Clinical Pharmacology or related discipline

Job description

BridgeBio in San Francisco seeks a Senior Director, Clinical Pharmacology to lead pharmacology strategies across clinical programs and PK/PD modeling. This hybrid, cross‑functional role focuses on external CRO oversight and regulatory interactions.

The position requires 10+ years in biotech/pharma, strong modeling expertise, and experience in pediatric development where possible. BridgeBio offers a competitive compensation package and comprehensive benefits.