Senior Director, Cell & Gene Therapy Drug Product

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 230,000 - 345,000; Full time

Job summary

Vertex Pharmaceuticals seeks a highly skilled leader to head drug product process development for cell and gene therapies at our Boston Seaport R&D site. The Senior Director will set strategy for formulation, cryopreservation, fill-finish, and administration-ready presentation, guiding programs from early development through commercialization.

The role requires deep autologous/allogeneic therapy experience, strong biologics drug product insight, and collaboration across process development,

Qualifications

• PhD required with commensurate experience in drug product development for cell and gene therapies.
• Experience leading autologous and allogeneic cell therapy programs is highly preferred.
• Strong track record in cGMP drug product development, tech transfer, and lifecycle management.

Responsibilities

• Provide strategic, scientific, and organizational leadership for drug product process development across the cell and gene therapy portfolio.
• Lead formulation, cryopreservation, fill-finish, and administration-ready product presentation.
• Drive technology transfer to GMP facilities and external partners with risk-based decision making.
• Oversee aseptic fill and finish processes for advanced therapies and define scalable, phase-appropriate processes.
• Collaborate across MSAT, Quality, Regulatory, and Supply Chain to ensure compliant strategies.
• Support CMC regulatory submissions and health authority interactions.

Skills

Technical leadership

Executive presence

Cross-functional collaboration

Strategic planning

Communication skills

Decision making under ambiguity

Education

PhD in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, Cryobiology, Bioengineering or related discipline

Job description

Vertex Pharmaceuticals seeks a highly skilled leader to head drug product process development for cell and gene therapies at our Boston Seaport R&D site. The Senior Director will set strategy for formulation, cryopreservation, fill-finish, and administration-ready presentation, guiding programs from early development through commercialization.

The role requires deep autologous/allogeneic therapy experience, strong biologics drug product insight, and collaboration across process development,