Senior Computational Pathology Scientist (AI-Driven IHC)

Alimentiv 2; San Diego (CA); On-site; USD 150,000 - 190,000; Full time

Job summary

AcelaBio is a CAP- and CLIA-accredited specialty histopathology laboratory in San Diego seeking a hands-on scientist to lead assay development and image analysis for sponsor studies. Build and optimize IHC, mIF, and ISH assays and develop AI-assisted image analysis pipelines while collaborating with pathologists, technicians, and business teams.

The role requires 7+ years in IHC/IF assay development and image analysis in regulated environments, with experience in Visiopharm/HALO and exposure to

Qualifications

• Graduate degree (M.Sc. or Ph.D.) in a relevant scientific discipline (pathology, cell biology, molecular biology, biomedical engineering, or related field).
• 7 or more years of hands-on experience in IHC/IF assay development and image analysis in a CRO, biopharma, or regulated research environment.
• Demonstrated experience building image analysis algorithms or pipelines in platforms such as Visiopharm, HALO, or similar.
• Exposure to spatial biology platforms (e.g., 10x Visium, Xenium, Akoya PhenoCycler) is a strong asset.

Responsibilities

• Design, develop, optimize, and validate immunostaining assays including single‑plex IHC, multiplex immunofluorescence (mIF), in situ hybridization (ISH), and spatial biology platforms.
• Define analytical endpoints, scoring strategies, and QC metrics aligned with assay performance requirements.
• Develop, validate, and maintain image analysis pipelines using platforms such as Visiopharm, HALO, or equivalent software.
• Build and implement AI/machine learning algorithms for tissue segmentation, cell phenotyping, and biomarker quantification.
• Ensure traceability, reproducibility, and thorough documentation of all analysis workflows.
• Contribute to assay validation documentation, analytical reports, and regulatory aligned deliverables.
• Partner with histotechnicians to support hands‑on assay troubleshooting and knowledge transfer.

Skills

IHC/IF assay development

Image analysis

AI/ML in histopathology

Regulatory/GxP

English communication

Project management

Education

M.Sc. or Ph.D. in a relevant field

Tools

Visiopharm

HALO

Job description

AcelaBio is a CAP- and CLIA-accredited specialty histopathology laboratory in San Diego seeking a hands-on scientist to lead assay development and image analysis for sponsor studies. Build and optimize IHC, mIF, and ISH assays and develop AI-assisted image analysis pipelines while collaborating with pathologists, technicians, and business teams.

The role requires 7+ years in IHC/IF assay development and image analysis in regulated environments, with experience in Visiopharm/HALO and exposure to