Senior Computational Designer, Protein AI & Discovery

TWIST BIOSCIENCE; San Francisco (CA); On-site; USD 151,000 - 181,000; Full time

Job summary

Twist Bioscience seeks a Senior or Staff Computational Scientist to develop AI and computational solutions for protein design, discovery, and characterization in a hands-on, impact-driven role.

You will work across computational biology, machine learning, and experimental science, collaborating with research scientists, software engineers, and customer-facing teams. The base cash compensation for this California-based role is provided with bonus and equity opportunities.

Qualifications

• Minimum of 5 years of industry experience with a PhD.
• PhD in computational biology, bioinformatics, machine learning, computer science, protein science, or a related field.
• Extensive experience developing algorithms for protein design, engineering, discovery, or sequence analysis.
• Demonstrated experience developing and applying AI/ML methods to proteins or other biological sequences.
• Strong understanding of protein language models (PLMs) and protein sequence-structure-function relationships.
• Experience analyzing NGS data from biological selection, screening, or related workflows.

Responsibilities

• Develop algorithms that integrate protein sequences with NGS and experimental data to derive insights that inform subsequent experiments and design cycles.
• Identify high-impact opportunities for new algorithms and AI-enabled capabilities, lead their development from concept through experimental validation, and translate successful approaches into reusable tools for research programs.
• Develop AI/ML methods for designing, evaluating, and optimizing therapeutic protein sequences.
• Apply protein language models (PLMs) and related approaches to sequence generation, property prediction, and candidate prioritization.
• Partner with software and bioinformatics teams to integrate models and analytical workflows into scalable research systems.
• Lead computational analyses for protein discovery programs, including sequence selection, clone prioritization, and characterization.
• Collaborate across computational, experimental, engineering, and customer-facing teams to translate scientific needs into practical solutions.
• Move flexibly between research, software development, analysis, and troubleshooting as program priorities evolve.

Skills

Python

PyTorch

TensorFlow

Protein design

Machine learning

Communication

Education

PhD in computational biology

Tools

NumPy

Jupyter

Git

Docker

Job description

Twist Bioscience seeks a Senior or Staff Computational Scientist to develop AI and computational solutions for protein design, discovery, and characterization in a hands-on, impact-driven role.

You will work across computational biology, machine learning, and experimental science, collaborating with research scientists, software engineers, and customer-facing teams. The base cash compensation for this California-based role is provided with bonus and equity opportunities.