Senior Bioinformatics Scientist: DNA Synthesis & Protein

Twist Bioscience Corporation; South San Francisco (CA); Sur place; USD 135 000 - 173 000; Plein temps

Avantages offerts par ce poste

Bonus

Equity

Benefits

Résumé du poste

Twist Bioscience Corporation seeks a Senior Bioinformatics Scientist to join the Scientific Computing team, developing computational methods and predictive models to interpret biological data and guide product development. You will collaborate across sequencing, DNA synthesis, and protein solutions, building workflows and evaluating methods to improve experimental outcomes.

Strong computational skills and scientific judgment are essential for translating open-ended questions into actionable

Qualifications

• Ph.D. with 3+ years, or Master’s 6+ years, in bioinformatics or related field.
• Strong Python programming skills and NGS data experience.
• Experience building reproducible workflows with Nextflow.
• Ability to develop and evaluate computational algorithms and models.
• Solid statistics, experimental design, and critical interpretation of results.
• Ability to collaborate with experimental scientists and explain complex findings.

Responsabilités

• Develop novel computational methods and algorithms supporting DNA synthesis, sequence analysis, and protein characterization.
• Partner with experimental scientists to formulate hypotheses, design experiments, and interpret results that guide product and process development.
• Analyze NGS and other experimental datasets to identify biological patterns, understand sources of variability, and investigate unexpected outcomes.
• Apply statistical methods, machine learning, and predictive modeling to connect sequence and experimental features with product quality and performance.
• Evaluate and validate analytical approaches, including their accuracy, limitations, and applicability across experimental conditions.
• Develop reproducible analysis pipelines using Nextflow and other scientific computing tools to support research and method evaluation.
• Communicate findings and recommendations to scientific and cross-functional stakeholders, and collaborate with engineers to translate successful methods into broader use.
• Explore new technologies and analytical approaches as research priorities evolve.

Connaissances

Python programming

NGS analysis

Statistics & experimental design

Machine learning

Reproducible analysis workflows

Communication with scientists

Formation

Ph.D. in bioinformatics / computational biology

Master's degree in a related field

Bachelor's degree or equivalent experience

Outils

Nextflow

Description du poste

Twist Bioscience Corporation seeks a Senior Bioinformatics Scientist to join the Scientific Computing team, developing computational methods and predictive models to interpret biological data and guide product development. You will collaborate across sequencing, DNA synthesis, and protein solutions, building workflows and evaluating methods to improve experimental outcomes.

Strong computational skills and scientific judgment are essential for translating open-ended questions into actionable