Senior Computational Biologist – ctDNA & Translational Genomics

Memorial Sloan Kettering Cancer Center; Street (MD); Hybrid; USD 114,000 - 182,000; Full time

Benefits offered by this job

Hybrid work model

Collaborative research environment

Job summary

Memorial Sloan Kettering Cancer Center in NYC is seeking a Senior Computational Biologist to develop and apply computational methods for liquid biopsy, clonal hematopoiesis, and translational cancer genomics research. Hybrid work with MSK-ACCESS and CMO-CH analyses will involve close collaboration with clinical, laboratory, and computational teams.

The role emphasizes building scalable analysis workflows, statistical modeling, and contributing to manuscripts and grants in a multidisciplinary

Qualifications

• Master's degree with relevant experience or PhD in Computational Biology, Bioinformatics, Statistics, Computer Science, or a related field.
• Strong programming skills in Python and/or R.
• Experience analyzing NGS or large-scale genomic datasets.
• Experience with workflow management systems such as Nextflow, Snakemake, CWL, or WDL.
• Experience working in Linux, HPC, and/or cloud environments.
• Proficiency with Git/GitHub and container technologies such as Docker or Apptainer/Singularity.
• Strong statistical analysis and scientific communication skills.

Responsibilities

• Analyze and interpret next-generation sequencing data from MSK-ACCESS, CMO-CH, and related assays.
• Lead computational analyses of ctDNA, clonal hematopoiesis, treatment response, and clinical outcomes data.
• Develop, automate, and maintain scalable, reproducible genomic analysis workflows.
• Build statistical and predictive models integrating genomic and clinical datasets.
• Collaborate with investigators across computational, laboratory, and clinical research teams.
• Contribute to manuscripts, grants, presentations, and translational research initiatives.

Skills

Python

R

Statistical analysis

Scientific communication

Collaboration

Education

Master's degree or PhD in Computational Biology, Bioinformatics, Statistics, Computer Science

Tools

Nextflow

Snakemake

CWl

WDL

Linux

HPC

Cloud platforms

Git/GitHub

Docker

Apptainer/Singularity

Job description

Memorial Sloan Kettering Cancer Center in NYC is seeking a Senior Computational Biologist to develop and apply computational methods for liquid biopsy, clonal hematopoiesis, and translational cancer genomics research. Hybrid work with MSK-ACCESS and CMO-CH analyses will involve close collaboration with clinical, laboratory, and computational teams.

The role emphasizes building scalable analysis workflows, statistical modeling, and contributing to manuscripts and grants in a multidisciplinary